Publications by authors named "Patrick J Fehrenbach"
Article Synopsis
- This study explores how regulatory T cells (Tregs) behave in inflammatory bowel diseases like Crohn's disease, focusing on their metabolic processes that impact gut homeostasis.
- Researchers used various advanced techniques (like electron microscopy and mass cytometry) to analyze Tregs' cellular structures and functions in humans and murine models of colitis.
- Key findings show that inhibiting a specific protein (VDAC1) disrupts Treg metabolism and increases sensitivity to inflammation, while manipulating metabolic pathways can restore proper Treg function and potentially inform new therapeutic strategies for inflammatory diseases.
Background & Aims: Incapacitated regulatory T cells (Tregs) contribute to immune-mediated diseases. Inflammatory Tregs are evident during human inflammatory bowel disease (IBD); however, mechanisms driving the development of these cells and their function are not well understood. Therefore, we investigated the role of cellular metabolism in Tregs relevant to gut homeostasis.
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