A Criterion-based Approach for the Systematic and Transparent Extrapolation of Clinical Trial Survival Data.

Trial data often does not cover a sufficiently long period of time to truly capture time-toevent endpoints, however, Health Technology Assessment (HTA) bodies often require overall survival (OS) and progression-free survival (PFS) estimates. Often, significant survival effects are found beyond the time period observed in clinical trials, thus, extrapolation of trial results is required for health economic and HTA evaluations. This paper looks at different techniques that can be used to extrapolate trial data, as well as criteria that should be used to select the most appropriate technique.