Publications by authors named "Patrick F Wagler"
Article Synopsis
- Nanoscale synthetic biology can improve by using programmable microfluidic chips for handling DNA in small volumes, facilitating better integration with biochemical arrays like microwell plates.
- The study introduces a simple, passive microfluidic device that allows for customizable droplet generation and mixing for DNA testing, bypassing the complexity of traditional microvalve systems.
- The researchers demonstrated that this device could effectively create and verify a DNA test library by combining standard DNA assembly techniques with on-chip operations, confirming their results through various tests like gel electrophoresis and DNA sequencing.
The topic addressed is that of combining self-constructing chemical systems with electronic computation to form unconventional embedded computation systems performing complex nano-scale chemical tasks autonomously. The hybrid route to complex programmable chemistry, and ultimately to artificial cells based on novel chemistry, requires a solution of the two-way massively parallel coupling problem between digital electronics and chemical systems. We present a chemical microprocessor technology and show how it can provide a generic programmable platform for complex molecular processing tasks in Field Programmable Chemistry, including steps towards the grand challenge of constructing the first electronic chemical cells.
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