Publications by authors named "Patrick DeMol"
Context: The Democratic Republic of Congo (DRC), one of the most malaria-affected countries worldwide, is a potential hub for global drug-resistant malaria. This study aimed at summarizing and mapping surveys of malaria parasites carrying molecular markers of drug-resistance across the country.
Methods: A systematic mapping review was carried out before July 2023 by searching for relevant articles through seven databases (PubMed, Embase, Scopus, African Journal Online, African Index Medicus, Bioline and Web of Science).
Evaluation of the usefulness of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine in a context with increased resistance of Plasmodium falciparum in Kingasani Hospital, Kinshasa in the Democratic Republic of Congo.
Infect Genet Evol
October 2021
Article Synopsis
- IPTp-SP faces challenges due to rising resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine, but its effects on maternal and newborn health were examined in a study involving 844 laboring women in Kinshasa, DRC.
- The study found that maternal malaria was present in 10.8% of women at delivery, linked to higher instances of fever and anemia, while a significant mutation profile in the malaria parasites suggested ongoing susceptibility to SP.
- Although IPTp-SP did not reduce maternal malaria, it showed a protective effect against negative pregnancy outcomes, such as maternal anemia, shortened gestation periods, and low birth weights, particularly with three or more doses administered.
Background: This study aimed to estimate the socio-economic costs of uncomplicated malaria and to explore health care-seeking behaviours that are likely to influence these costs in the Democratic Republic of Congo (DRC), a country ranked worldwide as the second most affected by malaria.
Methods: In 2017, a cross-sectional survey included patients with uncomplicated malaria in 64 healthcare facilities from 10 sentinel sites of the National Malaria Control Programme (NMCP) in the DRC. A standard questionnaire was used to assess health care-seeking behaviours of patients.
Background: In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype.
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- The study aimed to assess the antiplasmodial effectiveness of 12 plant species used traditionally in Benin for treating malaria.
- The researchers tested various crude extracts (dichloromethane, methanol, and total aqueous) for their ability to inhibit the growth of both chloroquine-sensitive and resistant strains of Plasmodium falciparum.
- Among the plants tested, Acanthospermum hispidum and Keetia leucantha showed the most promising antiplasmodial activity with low cytotoxicity, supporting their traditional medicinal use.