Publications by authors named "Patrick Coipeau"
Background Aims: Advances in bone tissue engineering with mesenchymal stromal cells (MSC) as an alternative to conventional orthopedic procedures has opened new horizons for the treatment of large bone defects. Bone marrow (BM) and trabecular bone are both sources of MSC. Regarding clinical use, we tested the potency of MSC from different sources.
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- The study investigated the occurrence of gastrointestinal side effects (GSE) and liver toxicity in patients treated with rifampicin for bone and joint infections.
- Researchers measured rifampicin plasma levels before and after dosage, noting that about 28% of patients experienced GSE during treatment.
- The analysis found no correlation between rifampicin levels and GSE, suggesting that monitoring rifampicin concentrations is not useful for managing these side effects.
Pathological osteolyses are considered a consequence of a disturbance in the mechanisms that govern the bone remodeling, mainly the communication between osteoclasts and osteoblasts. Osteoprotegerin (OPG) and receptor activator of NF-kappaB ligand (RANKL) are newly discovered molecules that play a key role in these communications. RANKL is essential for osteoclast differentiation via its receptor RANK located on the osteoclast membrane.
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