Publications by authors named "Patrick C Thien"
Article Synopsis
- Extraocular electrical stimulation can protect retinal cells but currently relies on patients frequently setting up external electrodes, which is inconvenient.
- A new minimally-invasive implant has been developed to provide a reliable method for chronic electrical stimulation of the retina, aimed at improving patient adherence to treatment.
- In a study with adult felines, the device showed surgical and stimulation safety with no adverse effects, stable electrode performance, and no significant changes to retinal health, suggesting it could be a viable long-term solution.
Purpose: Following successful clinical outcomes of the prototype suprachoroidal retinal prosthesis, Bionic Vision Australia has developed an upgraded 44-channel suprachoroidal retinal prosthesis to provide a wider field of view and more phosphenes. The aim was to evaluate the preclinical passive safety characteristics of the upgraded electrode array.
Methods: Ten normal-sighted felines were unilaterally implanted with an array containing platinum electrodes (44 stimulating and 2 returns) on a silicone carrier near the area centralis.
Purpose: The resolution provided by present state-of-the-art retinal prostheses is severely limiting for recipients, partly due to the broad spread of activation in the retina in response to monopolar (MP) electrical stimulation. Focused multipolar (FMP) stimulation has been shown to restrict neural activation in the cochlea compared to MP stimulation. We extended the FMP stimulation technique to a two-dimensional electrode array and compared its efficacy to MP and hexapolar (HP) stimulation in the retina.
View Article and Find Full Text PDFPurpose: To assess the safety and efficacy of chronic electrical stimulation of the retina with a suprachoroidal visual prosthesis.
Methods: Seven normally-sighted feline subjects were implanted for 96-143 days with a suprachoroidal electrode array and six were chronically stimulated for 70-105 days at levels that activated the visual cortex. Charge balanced, biphasic, current pulses were delivered to platinum electrodes in a monopolar stimulation mode.