Publications by authors named "Patrick B Murphy"

Introduction: Older age is a well-established risk factor for withdrawal of life-sustaining therapy (WDLST) and discharge to hospice (DH) in traumatic brain injury (TBI). However, a paucity of data exists in identifying factors associated with end-of-life (EoL) care in younger patients with TBI. We sought to identify hospital and patient factors associated with EoL care and timing of EoL care in younger adults with severe TBI.

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  • The study investigates the safety of observing patients with small concurrent traumatic hemopneumothorax (HPTX), finding that 74% of patients were managed with observation instead of immediate tube thoracostomy (TT).
  • Results indicate that patients under observation experienced lower rates of pulmonary complications and shorter hospital stays compared to those who underwent early TT.
  • However, observation had a notable failure rate, with many patients needing further intervention, but those who did fail showed outcomes similar to those who got immediate TT.
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  • Sniff nasal inspiratory pressure (SNIP) is a method to evaluate respiratory muscle strength, particularly in neuromuscular diseases like ALS, and the effects of nostril occlusion and mouth sealing on SNIP measurements were examined.
  • A study involving 81 participants found that occluding the contralateral nostril significantly increased SNIP measurements across all groups, while opening the mouth led to a notable decrease in SNIP values.
  • The results highlight the importance of proper technique in measuring SNIP, as using nostril occlusion could lead to fewer individuals qualifying for non-invasive ventilation, affecting clinical decisions and longitudinal studies.
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Since its inception, the specialty of acute care surgery has evolved and now represents a field with a broad clinical scope and large variations in implementation and practice. These variations produce unique challenges and there is no consistent definition of the scope, intensity or value of the work performed by acute care surgeons. This lack of clarity regarding expectations extends to surgeons and non-surgeons outside of our specialty, compounding difficulties in advocacy at the local, regional and national levels.

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  • Recurrent pneumothorax (rPTX) is a common issue after removing thoracostomy tubes in chest trauma patients, and traditional chest X-rays (CXR) are used to detect it, but bedside ultrasound (UPUS) offers a low-cost, radiation-free alternative.
  • A study with 92 patients aimed to determine the best timing for UPUS after tube removal, revealing that ultrasound performed at 3 hours post-removal had the highest sensitivity for detecting clinically concerning rPTX.
  • The findings suggest that rPTX size stabilizes by 4 hours, indicating that if no symptoms are present, further imaging beyond this timeframe may not be necessary.*
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Introduction: Gallstone disease is one of the most common surgical diagnoses in the United States. Notably absent from the literature is the patient's perspective on priorities in management. Understanding patient values will assist surgeons and systems in achieving high-quality, patient-focused care for biliary disease.

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  • - This review summarizes the current understanding of the overlap syndrome (OVS) between chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), highlighting high prevalence rates among patients of both conditions.
  • - Patients with OVS experience severe nocturnal oxygen deficiency and systemic inflammation, which are linked to a higher risk of cardiovascular disease and increased mortality.
  • - While observational studies indicate that using positive airway pressure therapy can enhance survival and decrease COPD flare-ups, further randomized controlled trials are necessary to validate these results.
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Background: Patients who require emergency general surgery (EGS) are at a substantially higher risk for perioperative morbidity and mortality than patients undergoing elective general surgery. The acute care surgery (ACS) model has been shown to improve EGS patient outcomes and cost-effectiveness. A recent systematic review has shown extensive heterogeneity in the structure of ACS models worldwide.

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Introduction: Retained hemothorax (HTX) is a common complication following thoracic trauma. Small studies demonstrate the benefit of thoracic cavity irrigation at the time of tube thoracostomy (TT) for the prevention of retained HTX. We sought to assess the effectiveness of chest irrigation in preventing retained HTX leading to a secondary surgical intervention.

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Background: Damage control surgery aims to control hemorrhage and contamination in the operating room (OR) with definitive management of injuries delayed until normal physiology is restored in the intensive care unit (ICU). There are limited studies evaluating the use of damage control thoracotomy (DCT) in trauma, and the best method of temporary closure is unclear.

Methods: A retrospective review of trauma patients at two level I trauma centers who underwent a thoracotomy operation was performed.

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  • Delays in starting VTE prophylaxis for patients with traumatic brain injury (TBI) remain an issue despite existing guidelines, prompting a hypothesis that an expanded Trauma Program Performance Improvement (PI) team will enhance timely care and reduce complications.
  • A retrospective review analyzed TBI patients before and after the expansion of the Trauma PIPS team over two separate years, excluding those with critical conditions or early interventions.
  • Results showed significant reductions in initiation time for VTE prophylaxis and increased administration rates, leading to lower VTE event rates without raising bleeding incidents, confirming the effectiveness of the multidisciplinary team's efforts.
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  • The study investigates the impact of exacerbations of Chronic Obstructive Pulmonary Disease (ECOPD) on global mortality and hospital readmission rates after hospitalization.
  • The analysis included data from 65,945 COPD patients, revealing a 6.2% in-hospital mortality rate and significant post-discharge mortality and readmission rates at various intervals.
  • Researchers emphasize the need for standardized management of ECOPD and suggest that policymakers prioritize funding for effective therapies to reduce the incidence of recurrent hospitalizations.
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  • The study focuses on the effectiveness and safety of early venous thromboembolism chemoprophylaxis in traumatic brain injury patients requiring neurosurgery, a group often excluded from previous research.
  • Conducted as a retrospective review at a level I trauma center from 2016 to 2020, the study compared patients who received early chemoprophylaxis (within 72 hours of surgery) to those who had it later.
  • Results showed that early initiation significantly reduced venous thromboembolism rates without increasing the risk of worsening intracranial hemorrhage or the need for further surgical interventions.
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Background: Not all hypercapnic COPD patients benefit from home noninvasive ventilation (NIV), and mechanisms through which NIV improves clinical outcomes remain uncertain. We aimed to identify "responders" to home NIV, denoted by a beneficial effect of NIV on arterial partial pressure of carbon dioxide (), health-related quality of life (HRQoL) and survival, and investigated whether NIV achieves its beneficial effect through an improved .

Methods: We used individual patient data from previous published trials collated for a systematic review.

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Background: Non-aortic arterial injuries are common and are associated with high morbidity and mortality. Historically, open surgical repair (OSR) was the conventional method of repair. With recent advancements in minimally invasive techniques, endovascular repair (ER) has gained popularity.

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Unlabelled: Significant inconsistencies in respiratory care provision for Duchenne muscular dystrophy (DMD) are reported across different specialist neuromuscular centres in the UK. The absence of robust clinical evidence and expert consensus is a barrier to the implementation of care recommendations in public healthcare systems as is the need to increase awareness of key aspects of care for those living with DMD. Here, we provide evidenced-based and/or consensus-based best practice for the respiratory care of children and adults living with DMD in the UK, both as part of routine care and in an emergency.

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Background: The optimal time to initiate venous thromboembolism (VTE) chemoprophylaxis (VTEp) after blunt solid organ injury remains controversial, as VTE mitigation must be balanced against bleeding promulgation. Evidence from primarily small, retrospective, single-center work suggests that VTEp ≤48 hours is safe and effective. This study was undertaken to validate this clinical practice.

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  • Respiratory muscle weakness can lead to ineffective coughing, increasing the risk of lower respiratory infections in patients with neuromuscular diseases; Mechanical insufflation-exsufflation (MIE) enhances cough function, but optimal techniques remain unclear.
  • The study investigates the effects of high-pressure MIE (HP-MIE) versus low-pressure MIE (LP-MIE) on lung recruitment, respiratory drive, and patient comfort in patients with respiratory muscle weakness.
  • Results show HP-MIE significantly improves cough peak flow without affecting lung recruitment or breathing comfort but may lead to upper airway closure and discomfort in patients with severe weakness.
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