Publications by authors named "Patrick B Collins"
Article Synopsis
- - This study explores the use of palovarotene, an oral drug, to help improve muscle recovery in rats with volumetric muscle loss, which typically results in severe functional impairment.
- - Researchers created a major muscle defect in rats and observed significant improvements in muscle strength, with a 38% increase in peak torque after 4 weeks of treatment with palovarotene compared to untreated rats.
- - The findings suggest that palovarotene may reduce fibrous scarring at the injury site and could be useful in developing new regenerative treatments for muscle injuries, though further research is needed to fully understand its effects and potential in combination with other therapies.
In a double-blind, crossover, randomized and placebo-controlled trial; 28 men and women ingested a placebo (PLA), 3 g of creatine nitrate (CNL), and 6 g of creatine nitrate (CNH) for 6 days. Participants repeated the experiment with the alternate supplements after a 7-day washout. Hemodynamic responses to a postural challenge, fasting blood samples, and bench press, leg press, and cycling time trial performance and recovery were assessed.
View Article and Find Full Text PDFIn a double-blind, randomized and crossover manner, 25 resistance-trained participants ingested a placebo (PLA) beverage containing 12 g of dextrose and a beverage (RTD) containing caffeine (200 mg), β-alanine (2.1 g), arginine nitrate (1.3 g), niacin (65 mg), folic acid (325 mcg), and Vitamin B12 (45 mcg) for 7-days, separated by a 7-10-day.
View Article and Find Full Text PDFBackground: Diabetes mellitus (DM) is associated with a significant polyuria and natriuesis as well as increased plasma aldosterone and anti-diuretic hormone arginine vasopressin (AVP). This study aimed to determine whether diabetic kidneys compensate for the urinary sodium and water losses by increasing apical targeting of epithelial sodium channel (ENaC) subunits and aquaporin-2 (AQP2) in the collecting duct, in addition to the previously observed changes in ENaC subunit protein expression in different kidney zones.
Methods: Female rats were investigated 2 weeks after induction of DM by streptozotocin administration.