Publications by authors named "Patrick A Shearer"
Article Synopsis
- T cell responses to infections and cancer are guided by conventional dendritic cells (cDCs) in lymph nodes, which interact with migratory cDCs that transport antigens from the site of challenge.
- Research reveals that both tissue and lymph node cDCs work together, influenced by contextual signals, to determine the quality of T cell activation.
- The study shows that in different environments, such as tumors versus infections, cDC activation varies, affecting how antigens are processed and T cell responses are directed in the lymph nodes.
