Publications by authors named "Patricia de Souza Villa"
Activation of the serotonergic 5-HT1A receptor in the paraventricular nucleus of the hypothalamus inhibits water intake and increases urinary excretion in water-deprived rats.
Regul Pept
October 2008
Article Synopsis
- The paraventricular nucleus (PVN) contains various neuron subgroups, including those with 5-HT(1A) receptors that play a role in regulating hormones like oxytocin (OT), which affects water balance.
- A study showed that activating these 5-HT(1A) receptors in the PVN led to reduced water intake and increased urine output in rats after 24 hours of being water-deprived.
- The research indicates that the inhibitory effects on water consumption and the increases in urine formation in dehydrated rats are mediated by the action of serotonergic 5-HT(1A) receptors in a specific area of the PVN.
Hypothalamic paraventricular nucleus (PVN) has an important role in the regulation of water and sodium intake. Several researches described the presence of 5-HT(1) receptors in the central nervous system. 5-HT(1A) was one of the prime receptors identified and it is found in the somatodendritic and post-synaptic forms.
View Article and Find Full Text PDFThe aim of the present study was to analyze the role of alpha1, alpha2-adrenoceptors, and the effects of losartan and PD123319 (selective ligands of the AT1 and AT2 angiotensin receptors, respectively) injected into the paraventricular nucleus (PVN) on the diuresis, natriuresis, and kaliuresis induced by administration of adrenaline into the medial septal area (MSA). Male Holtzman rats with a stainless steel cannula implanted into the MSA and bilaterally into the PVN were used. The administration of adrenaline into the MSA increased in a dose-dependent manner the urine, sodium, and potassium excretions.
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