and polymorphisms in Brazilian patients with nonalcoholic fatty liver disease.

Background: Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease worldwide, with significant morbidity associated with nonalcoholic steatohepatitis (NASH). Genome-wide association studies demonstrated that the variants rs738409 C/G in the and rs58542926 C/T in the genes are determinants of inter-individual and ethnicity-related differences in hepatic fat content and NAFLD progression.

Aim: To investigate and genotype frequency and their association with NAFLD development and progression in Brazilian patients.

Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity.

Objective: Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity.

Association between tryptophan hydroxylase-2 gene and late-onset depression.

Objective: The aim of this study was to examine the association between polymorphisms (SNP) in the tryptophan hydroxylase-2 (TPH2) gene and late-onset depression (LOD) in the Brazilian population.

Methods: We genotyped 8 tag SNPs in the TPH2 gene in 84 outpatients with LOD and 79 individuals belonging to the comparison group to investigate an association between the TPH2 gene and LOD.

Results: Our findings suggested an association between tag SNP rs4565946 heterozygous C/T (p = 0.