Publications by authors named "Patricia de Araujo Manfroi"
Mol Cell Endocrinol
September 2021
Article Synopsis
- Papillary thyroid cancer (PTC) is more common in women, with studies suggesting estrogen's role in increasing this incidence, particularly through 17β-estradiol (E2) affecting thyroid cell behavior.
- The study focuses on G protein estrogen receptor 1 (GPER1) gene and protein expression in PTC versus non-malignant thyroid tissues, revealing lower GPER1 levels in PTC and its association with clinical features like metastasis, female gender, and BRAF mutations.
- Results indicate that GPER1 may influence PTC tumorigenesis and suggests it could be a potential target for therapy, calling for more research into its functions in both normal and cancerous thyroid tissues.
Article Synopsis
- Thyroid cancer is becoming more common, especially in women, and a substance called 17-β-estradiol (E2) might help thyroid cancer cells grow through a receptor known as GPER1.
- The study looked at different research papers to learn more about GPER1's role in the thyroid, focusing on how it may affect cancer cells.
- Though there are some signs that GPER1 could make thyroid cancer cells grow faster, there are not enough studies to draw clear conclusions about its exact role.
