Publications by authors named "Patricia Waszyk"
Ewing sarcoma (EwS) is associated with poor prognosis despite current multimodal therapy. Targeting of EWS-FLI1, the fusion protein responsible for its pathogenesis, and its principal downstream targets has not yet produced satisfactory therapeutic options, fueling the search for alternative approaches. Here, we show that the oncofetal RNA-binding protein LIN28B regulates the stability of EWS-FLI1 mRNA in ~10% of EwSs.
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- Melanoma patients resistant to RAF/MEK inhibitors often do not respond to other treatments like immune checkpoint inhibitors, highlighting the need for new treatment options.* -
- The small-molecule drug CX-6258 shows strong effectiveness against both sensitive and resistant melanoma cell lines by targeting and inhibiting Haspin kinase (HASPIN), which leads to decreased cell proliferation and elicits an immune response.* -
- CX-6258 not only demonstrates minimal toxicity to healthy immune cells and neurons but also shows promise in other cancers, suggesting it could be a viable therapy for overcoming drug resistance and enhancing the immune environment.*