Publications by authors named "Patricia Vuscan"
Article Synopsis
- The objective of the study was to analyze calcium-containing crystals in synovial fluid from knee osteoarthritis patients using Raman spectroscopy and assess the effects of calcite crystals on biological responses.
- The research involved collecting synovial fluid samples from 32 patients, identifying various crystals, and examining the immune responses of different cells exposed to calcite crystals.
- Findings revealed calcite crystals in the majority of samples, with distinct pro-inflammatory responses observed in immune cells and other joint cells, suggesting that understanding these crystals could lead to new treatment strategies for osteoarthritis.
Over the past decade, compelling evidence has unveiled previously overlooked adaptive characteristics of innate immune cells. Beyond their traditional role in providing short, non-specific protection against pathogens, innate immune cells can acquire antigen-agnostic memory, exhibiting increased responsiveness to secondary stimulation. This long-term de-facto innate immune memory, also termed trained immunity, is mediated through extensive metabolic rewiring and epigenetic modifications.
View Article and Find Full Text PDFcell wall component β-glucan has been extensively studied for its ability to induce epigenetic and functional reprogramming of innate immune cells, a process termed . We show that a high-complexity blend of two individual β-glucans from possesses strong bioactivity, resulting in an enhanced trained innate immune response by human primary monocytes. The training required the Dectin-1/CR3, TLR4, and MMR receptors, as well as the Raf-1, Syk, and PI3K downstream signaling molecules.
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