Publications by authors named "Patricia V Sanchez"
Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloid leukemia (AML).
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- Human leukemic stem cells (SL-ICs), identified in acute myelogenous leukemia (AML), are rare and can be found among various lineage marker-expressing cells, challenging the traditional cancer stem cell model!
- Using NOD/SCID/IL2Rγc-deficient mice for xenotransplantation, the study confirmed SL-ICs' presence in lineages (Lin+ cells) and indicated that these cells retain their ability to self-renew in secondary transplants!
- The findings highlight that AML stem cells display a greater phenotypic diversity than previously thought, suggesting that their characteristics are more plastic and not strictly limited to primitive hematopoietic cell markers.
Objective: To determine the response of bone marrow progenitor cells from patients with myelodysplastic syndromes (MDS) to culture in physiologic oxygen tension.
Methods: Methylcellulose progenitor assays using both unfractionated bone marrow mononuclear cells (MNCs) and purified CD34(+) progenitors were performed in atmospheric oxygen (18.6% O(2)) or one of two levels of hypoxia (1% and 3% O(2)).