Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.

Background: A wide range of ablative and non-surgical therapies are available for treating small hepatocellular carcinoma in patients with very early or early-stage disease and preserved liver function.

Objective: To review and compare the effectiveness of all current ablative and non-surgical therapies for patients with small hepatocellular carcinoma (≤ 3 cm).

Design: Systematic review and network meta-analysis.

The effectiveness of ablative and non-surgical therapies for early hepatocellular carcinoma: Systematic review and network meta-analysis of randomised controlled trials.

Background & Aims: Non-surgical therapies are frequently used for patients with early or very early hepatocellular carcinoma (HCC). The aim of this systematic review and network meta-analysis (NMA) was to evaluate and compare the effectiveness of ablative and non-surgical therapies for patients with small HCC.

Methods: Nine databases were searched (March 2021) along with clinical trial registries.

Mortality in late nineteenth-century Montreal: geographic pathways of contagion.

In the City of Montreal, 1881, the presence of three cultural communities with different profiles of economic status makes it possible to observe the way social settings affected survival over a lifetime. Regression models show culturally determined maternal factors dominant for infants, and persistent throughout childhood. For post-neonates, children aged 1-4, and adults aged 15-59 household poverty has a comparable effect.

Specificity of the jump-to-conclusions bias in deluded patients.

Objective: To investigate the specificity of the 'jump-to-conclusions' (JTC) bias in delusions.

Methods: Thirty-seven psychotic patients were divided into two separate groupings: (1) deluded versus non-deluded individuals and (2) individuals with and without a diagnosis of schizophrenia. Groups were compared on three reasoning tasks ('Beads' task, Wason's 2-4-6 task, and Wason's selection task).

Reconciling cross-sectional and longitudinal measures of fertility, Quebec 1890-1900.

In the absence of vital registration, studies of the onset and early phases of the fertility transition in North America have been seriously hampered and yet the seemingly early timing of the decline, the multi-ethnic nature of the population and continuous flow of immigrants from Europe suggest that North America has much to offer to this debate. This paper is primarily methodological drawing on parallel data for the city of Montreal and surrounding region. By reconciling cross-sectional census measures of fertility using the own-child methods (1901) with those derived from a longitudinal ten-year panel (1891-1901) using family reconstitution, it exposes some of the weaknesses and the potentials of the two methods most often currently used and the advantages of combining methods.