Publications by authors named "Patricia Simaku"
Article Synopsis
- - Respiratory fungal infections pose a serious health risk and existing animal models don't accurately mimic human disease, prompting the need for better research models.
- - This study used primary human airway epithelial cells (hAECs) to examine responses to two important fungal pathogens through single-cell RNA sequencing.
- - Findings showed that while both fungi caused cellular stress and inflammation, they impacted different cell types and pathways, highlighting unique stress responses that could lead to potential treatment targets.
Respiratory infections caused by the human fungal pathogen Aspergillus fumigatus are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory epithelium in disease pathogenesis has not been fully defined. Employing a primary human airway epithelial model, we demonstrate that fungal melanins potently block the post-translational secretion of the chemokines CXCL1 and CXCL8 independent of transcription or the requirement of melanin to be phagocytosed, leading to a significant reduction in neutrophil recruitment to the apical airway both in vitro and in vivo.
View Article and Find Full Text PDFInhibition of Bruton's tyrosine kinase (BTK) through covalent modifications of its active site (e.g., ibrutinib [IBT]) is a preferred treatment for multiple B cell malignancies.
View Article and Find Full Text PDFRespiratory infections caused by the human fungal pathogen are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory epithelium in disease pathogenesis has not been fully defined. Employing a primary human airway epithelial model, we demonstrate that fungal melanins potently block the post-translational secretion of the chemokines CXCL1 and CXCL8 independent of transcription or the requirement of melanin to be phagocytosed, leading to a significant reduction in neutrophil recruitment to the apical airway both and .
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