The relationship of angiogenic factors to maternal and neonatal manifestations of early-onset and late-onset preeclampsia.

Objective: An imbalance between angiogenic and antiangiogenic factors has been implicated in the pathogenesis and severity of preeclampsia. In this study, we evaluated serum levels of an angiogenic factor and an antiangiogenic factor - placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1), respectively - in pregnant women with preeclampsia, as well as evaluating the impact of those factors on maternal and fetal outcomes.

Method: We studied 44 pregnant women diagnosed with preeclampsia and admitted to an intensive care unit (ICU).