Publications by authors named "Patricia Pena-Sanfelix"
Background And Aims: Alcohol-associated liver disease (ALD) is a leading cause of liver-related mortality worldwide, with limited treatment options beyond abstinence and liver transplantation. Chronic alcohol consumption has been linked to magnesium (Mg 2+ ) deficiency, which can influence liver disease progression. The mechanisms underlying Mg 2+ homeostasis dysregulation in ALD remain elusive.
View Article and Find Full Text PDFArticle Synopsis
- Drug-induced liver injury (DILI), particularly from acetaminophen (APAP) overdose, is a major factor in acute liver failure and liver transplants in the Western world.
- Research shows that neddylation, a modification important for mitochondrial function, is increased in liver samples from APAP injury patients and mice with APAP overdose.
- The inhibitor MLN4924 reduces liver cell damage and enhances regeneration in APAP injury, and the study identifies crucial elements in this process, suggesting new avenues for targeted DILI treatments.
The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is SUMOylated in the tumor sections of patients with hepatocellular carcinoma in contrast to the surrounding tissue, as well as in human cell line and mouse models of the disease. SUMOylation of HuR promotes major cancer hallmarks, namely proliferation and invasion, whereas the absence of HuR SUMOylation results in a senescent phenotype with dysfunctional mitochondria and endoplasmic reticulum.
View Article and Find Full Text PDF