Publications by authors named "Patricia P Katz"

Article Synopsis
  • Coal miners in Appalachia show higher rates of depression and anxiety compared to other occupations, with 16.3% of surveyed individuals having mining experience.
  • The study used comprehensive surveys to assess PTSD, depression, and anxiety among men aged 50 and older, adjusting for various factors like trauma and smoking.
  • While coal mining correlated with increased depression (OR 1.6) and anxiety (OR 1.7), it was not directly linked to higher PTSD risk, emphasizing the need for targeted public health interventions for this population.
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Article Synopsis
  • The study aimed to evaluate how systemic lupus erythematosus (SLE) affects people's ability to perform daily activities independently, specifically instrumental and basic activities of daily living (IADLs and BADLs).
  • The research involved 436 participants, primarily female and Black, with over half reporting difficulties in IADLs like housekeeping and shopping, and significant limitations in BADLs such as bathing and dressing.
  • Results indicated that higher disease activity, along with factors like depression, stress, lower income, and older age, strongly correlated with limitations in daily activities, highlighting the need for strategies to improve quality of life for older individuals with SLE.
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Objective: Trauma history is associated with SLE onset and worse patient-reported outcomes; perceived stress is associated with greater SLE disease activity. Stress perceptions vary in response to life events and may be influenced by psychosocial factors. In an SLE cohort, we examined whether stressful events associated with perceived stress, whether psychosocial factors affected perceived stress, and whether these relationships varied by prior trauma exposure.

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Objective: We sought to describe fluid cognition and its correlates among individuals with systemic lupus erythematosus (SLE).

Methods: Participants (n = 199) were recruited from a population-based cohort for a single study visit (October 2019 to May 2022). Fluid cognition was measured via the National Institutes of Health Toolbox Fluid Cognition Battery (including episodic memory, working memory, attention and inhibitory control, processing speed, and cognitive flexibility domains) and expressed as age-corrected standard scores (mean 100, SD 15).

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Background: Social determinants of health are consistently associated with systemic lupus erythematosus (SLE) outcomes. However, social determinants of health are typically measured with conventional socioeconomic status factors such as income or education. We assessed the association of economic insecurities (ie, food, housing, health care, and financial insecurity) with patient-reported outcomes in a cohort of patients with SLE.

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Objective: As part of a Centers for Disease Control and Prevention-funded American College of Rheumatology (ACR) initiative, we sought to develop quality measures related to Patient Reported Outcome Measure (PROM) use for systemic lupus erythematosus (SLE) clinical care.

Methods: An expert workgroup composed of physician, patient, and researcher representatives convened to identify patient-reported outcome (PRO) domains of greatest importance to people with SLE. A patient advisory panel separately ranked domains.

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Objective: Racial and ethnic disparities in rheumatoid arthritis (RA) disease activity measures have been documented. We compared racial and ethnic differences in disease activity using multiple composite measures, including an objective measure, the multi-biochemical disease activity (MBDA) score.

Methods: Data are derived from the University of California, San Francisco RA Cohort, a longitudinal observational cohort.

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Objective: Most studies observing an association between depressive symptoms following lung transplantation and mortality are limited to depressive symptom measurement at a single time point, unrelated to allograft function. We aimed to test the association of depressive symptoms over multiple assessments with allograft dysfunction and with mortality.

Methods: We assessed depressive symptoms before and serially up to 3 years after lung transplantation in lung transplant recipients.

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Article Synopsis
  • - The study aimed to explore the relationship between rheumatoid arthritis (RA) disease activity and bone mineral density (BMD), specifically whether cumulative RA disease activity is linked to BMD levels.
  • - Researchers analyzed data from 161 RA participants over 12 years, revealing that lower disease activity was associated with higher BMD at the femoral neck, independent of usual osteoporosis risk factors.
  • - Findings indicate that maintaining low cumulative disease activity can positively impact bone health in RA patients, with consistent results even when using different measures of disease activity and other BMD sites.
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Background: Many coronavirus disease 2019 (COVID-19) survivors experience persistent symptoms, such as fatigue, dyspnea, and musculoskeletal pain. However, less is known about the impact of COVID-19 on longer term functional outcomes.

Objective: To evaluate patient-reported activity of daily living (ADL) function and fatigue symptoms 30 days after hospitalization for COVID-19.

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Sarcopenia is associated with disability and death. The optimal definition and clinical relevance of sarcopenia in lung transplantation remain unknown. To assess the construct and predictive validity of sarcopenia definitions in lung transplant candidates.

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Disability, depressive symptoms, and impaired health-related quality of life (HRQL) are common among patients with life-threatening respiratory compromise. We sought to determine if primary graft dysfunction (PGD), a syndrome of acute lung injury, attenuates improvements in patient-reported outcomes after transplantation. In a single-center prospective cohort, we assessed disability, depressive symptoms, and HRQL before and at 3- to 6-month intervals after lung transplantation.

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Objectives: Frailty in the general population is associated with poor health outcomes including low bone mass and osteoporotic fracture. The relationship between frailty and low bone mineral density (BMD) in rheumatoid arthritis (RA) is unknown. This study examined associations between frailty and BMD in RA, controlling for established osteoporosis risk factors.

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Background: Lung transplantation and related medications are associated with pathobiological changes that can induce frailty, a state of decreased physiological reserve. Causes of persistent or emergent frailty after lung transplantation, and whether such transplant-related frailty is associated with key outcomes, are unknown.

Methods: Frailty and health-related quality of life (HRQL) were prospectively measured repeatedly for up to 3 years after lung transplantation.

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Background: Poor patient-clinician communication around patient-reported outcomes (PROs) is a barrier to the effective management of rheumatoid arthritis (RA). We aimed to develop an RA 'dashboard' that could facilitate conversations about PROs and that would be acceptable to a wide range of patients, including English and Spanish speakers and patients with adequate or limited health literacy.

Methods: A diverse group of RA patients along with clinicians from two academic rheumatology clinics joined separate focus groups.

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Objective: Reduced physical function and frailty are common in rheumatoid arthritis (RA). However, relationships between frailty and changes in physical function and disease activity over time in RA are unknown. We tested whether frailty is a risk factor for worsening patient-reported physical function and disease activity in RA.

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Objective: Adverse childhood experiences (ACEs) are associated with poor adult health and immune dysregulation. The impact of ACEs on patients with autoimmune disease is unknown. The present study was undertaken to compare the prevalence of ACEs in patients with systemic lupus erythematosus (SLE) to a population-based survey estimate and to investigate relationships between ACEs and SLE outcomes.

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Objective: We examined quality measures for screening, diagnosis, and treatment of lupus nephritis (LN) among participants of the California Lupus Epidemiology Study across 25 different clinical sites to identify gaps in quality of care.

Methods: Data from 250 participants with lupus were analyzed across 3 sources (medical records, physician examination, and patient interviews). Overall performance on 8 quality measures was calculated separately for participants with and without LN.

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Inclusion of patient-reported outcomes is important in SLE clinical trials as they allow capture of the benefits of a proposed intervention in areas deemed pertinent by patients. We aimed to compare the measurement properties of health-related quality of life (HRQoL) measures used in adults with SLE and to evaluate their responsiveness to interventions in randomised controlled trials (RCTs). A systematic review was undertaken using full original papers in English identified from three databases: MEDLINE, EMBASE and PubMed.

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Objective: Most studies that have evaluated patient-reported outcomes, such as those utilizing the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 10a (PF10a) in rheumatoid arthritis (RA), have been performed in white and English-speaking populations. The aim of our study was to assess the measurement properties of the PF10a in a racially/ethnically diverse population with RA and to determine the effect of non-English language proficiency, insurance status, and race/ethnicity on the validity and responsiveness of the PF10a.

Methods: Data were abstracted from electronic health records for all RA patients seen in a university-based rheumatology clinic between 2013 and 2017.

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Frailty is associated with increased mortality among lung transplant candidates. We sought to determine the association between frailty, as measured by the Short Physical Performance Battery (SPPB), and mortality after lung transplantation. In a multicenter prospective cohort study of adults who underwent lung transplantation, preoperative frailty was assessed with the SPPB (n = 318) and, in a secondary analysis, the Fried Frailty Phenotype (FFP; n = 299).

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Objective: Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched controls, the causes for which remain unknown. We investigated contributions of RA characteristics, medication use, and body composition to low bone mineral density (BMD) in patients with RA.

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Rationale: The frail phenotype has gained popularity as a clinically relevant measure in adults with advanced lung disease and in critical illness survivors. Because respiratory disease and chronic illness can greatly limit physical activity, the measurement of participation in traditional leisure time activities as a frailty component may lead to substantial misclassification of frailty in pulmonary and critical care patients.

Objectives: To test and validate substituting the Duke Activity Status Index (DASI), a simple 12-item questionnaire, for the Minnesota Leisure Time Physical Activity (MLTA) questionnaire, a detailed questionnaire covering 18 leisure time activities, as the measure of low activity in the Fried frailty phenotype (FFP) instrument.

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Synopsis of recent research by authors named "Patricia P Katz"

  • - Patricia P. Katz's recent research primarily focuses on understanding the psychological and functional outcomes in patients with systemic lupus erythematosus (SLE) and other chronic conditions, including the impact of social determinants and psychosocial factors on health-related quality of life.
  • - Key findings indicate that economic insecurities significantly correlate with adverse patient-reported outcomes in SLE, while positive psychosocial factors may help mitigate perceived stress levels among individuals with and without trauma history.
  • - Additionally, Katz has investigated the limitations in daily living activities among SLE patients and developed quality measures for patient-reported outcomes, highlighting the importance of comprehensive assessment and care within rheumatological conditions.