Publications by authors named "Patricia Oliveira de Santana"
Pharmacological Modulation of the Ca/cAMP/Adenosine Signaling in Cardiac Cells as a New Cardioprotective Strategy to Reduce Severe Arrhythmias in Myocardial Infarction.
Fernando Sabia Tallo Patricia Oliveira de Santana Sandra Augusta Gordinho Pinto Rildo Yamaguti Lima Erisvaldo Amarante de Araújo
Pharmaceuticals (Basel)
October 2023
Article Synopsis
- Acute myocardial infarction (AMI) is a leading cause of serious heart issues, often resulting in dangerous heart rhythms due to a lack of blood flow to the heart followed by its restoration.
- The study explored how blocking L-type calcium channels with drugs (nifedipine and verapamil) and manipulating adenosine pathways could protect the heart against severe arrhythmias in rats.
- Results showed that these treatments reduced the occurrence of ventricular arrhythmias and blocks, but their effectiveness was diminished when specific blockers were used, suggesting a potential new approach to treat AMI-related heart problems in humans.