Effect of recombinant activated protein C and low-dose heparin on neutrophil-endothelial cell interactions in septic shock.

Objective: To examine the effects of recombinant activated protein C (rhAPC) and low-dose heparin on neutrophil-platelet-endothelial cell interactions in septic shock.

Design: Controlled experiments using phase contrast microscopy to study neutrophil, platelet, and endothelial cell interactions in flowing cell suspensions under simulated physiologic conditions.

Setting: University research laboratory.