Postinfectious bronchiolitis obliterans in children: the South American contribution.

Unlabelled: Postinfectious bronchiolitis obliterans (PIBO) is an infrequent chronic lung that causes irreversible obstruction and, or, obliteration of the smaller airways. This review particularly focuses on more than 30 studies from South America.

Conclusion: The initial PIBO event occurs in the early years of life and is strongly associated with adenovirus infection and the need for mechanical ventilator support.

Molecular and serological characterization of species B2 adenovirus strains isolated from children hospitalized with acute respiratory disease in Buenos Aires, Argentina.

Background: Between September 2000 and November 2005, approximately 10% of the retrospectively examined human adenovirus (HAdV)-positive pediatric cases of acute respiratory disease (ARD) requiring hospitalization at the Hospital Nacional de Pediatria Juan P. Garrahan in Buenos Aires, Argentina, were found to have a HAdV-B2 infection.

Objective: To characterize genetically and antigenically the HAdV-B2 virus isolates.

Congenital cystic adenomatoid malformation: clinical features, pathological concepts and management in 172 cases.

Objective: Congenital cystic adenomatoid malformation (CCAM) is the most common surgically resected pulmonary malformation in children. This retrospective study was undertaken to present the experience of 172 CCAM cases in a pediatric hospital.

Methods: Published series with a small number of patients reports details of lesions, progress and management.

Acute lower respiratory tract infections by adenovirus in children: histopathologic findings in 18 fatal cases.

Adenoviruses (Ads) are the 2nd-most common cause of acute lower respiratory tract infections of viral etiology in immunocompetent children who require hospitalization in Argentina. A new pathogenic genomic variant, Ad7h, has been identified and was associated with severe sequelae and a high mortality rate. A retrospective observational study was conducted in hospitalized children with acute lower respiratory tract infections between March 1988 and May 2005.

Molecular characterization of an adenovirus 3-16 intertypic recombinant isolated in Argentina from an infant hospitalized with acute respiratory infection.

An intertypic recombinant adenovirus with a serotype 3-like hexon gene and a serotype 16-like fiber (99% identical to that of the prototype strain of human adenovirus 16 [HAdV-16], Ch79) was isolated in Argentina from an infant admitted to the hospital with acute respiratory disease. Consistent with the results of molecular characterization, strain Arg827/04 was designated H3-F16.

Lower respiratory infections by adenovirus in children. Clinical features and risk factors for bronchiolitis obliterans and mortality.

Unlabelled: Adenovirus (Ad) respiratory infections have a profound impact in Argentina. Severe chronic disease and a high mortality rate are observed in children after acute lower respiratory infections (ALRI) by Ad.

Methods: A retrospective observational study was performed to describe clinical characteristics and to analyze risk factors for bronchiolitis obliterans (BO) and death in 415 children hospitalized with ALRI caused by Ad from March 1988 to May 2005.