Publications by authors named "Patricia Maria O Farrill-Romanillos"
Article Synopsis
- The study aimed to estimate how common skin issues are among Mexican patients with common variable immunodeficiency (CVID).
- It reviewed medical records of 36 patients and found that 70% experienced dermatological symptoms, with irritant contact dermatitis being the most prevalent.
- The research highlights the importance of recognizing skin conditions in CVID patients due to their potential complications, like a higher risk of infections.
Introduction: Up to 25% of patients with common variable immunodeficiency (CVID) debut with autoimmunity, which is related to the Freiburg classification, which is based on flow cytometry.
Objective: to determine the frequency and type of autoimmune diseases and their association with the Freiburg classification in adults with CVID.
Methods: A cross-sectional, analytical and observational study was carried out with 33 patients belonging to the Primary Immunodeficiency Clinic of a third level hospital, with a diagnosis of CVID.
[Patient with Good's syndrome and COVID-19. Report of a clinical case].
Rev Med Inst Mex Seguro Soc
July 2022
Background: The consequences of SARS-CoV-2 infection in patients with primary (now called "inborn errors of immunity") or secondary immunodeficiencies is still a matter of debate. There are few reports in the literature of patients with Good's syndrome and SARS-CoV-2 infection with variable outcomes.
Clinical Case: A 51-year-old male with diagnosis of Good's syndrome treated with intravenous human immunoglobulin (IVIG) at a replacement dose with application every 21 days and prophylaxis for P.
Article Synopsis
- Pollen-food syndrome (PFS) is an allergic reaction to proteins found in the pollen of various plants, mostly manifested when consuming certain raw fruits and vegetables that share similar proteins.
- The most commonly involved proteins include profilins, PR-10, and ns LTP, with birch-apple being the most typical example, affecting over 70% of birch-sensitized individuals.
- Diagnosis is often complex and may be missed, as symptoms mainly occur in the mouth but can lead to serious reactions like anaphylaxis; the primary treatment is an elimination diet since immunotherapy options are not widely available.
Background: Asthma has a global prevalence of 18%. In work-related asthma, there is an association between asthma and the exposure to dust, vapors, or fumes only at the workplace, in patients with or without a previous asthma diagnosis; it represents approximately 5-25% of the cases of adult onset asthma. In Mexico, the information about this topic is scarce.
View Article and Find Full Text PDFHumoral immune deficiencies (HID) comprise a group of diseases characterized by the impossibility to develop an effective immune response mediated by immunoglobulins (Ig). Patients with HID have infections caused by capped extracellular bacteria, mainly in the respiratory and/or gastrointestinal tract, and a higher predisposition to suffer from autoimmune diseases and cancer. Some of them are caused by well-defined genetic defects, while the cause of others is unknown.
View Article and Find Full Text PDFBackground: Chronic urticaria (CU) affects 5 % of the general population and it is associated with thyroid disease in up to 54 % of patients. There is scarce information on the activity of urticaria in patients with and without alterations in the thyroid function.
Objective: To compare the activity rate of urticaria using the UAS7 (Urticaria Activity Score 7) in patients with and without hypothyroidism.
Article Synopsis
- Intravenous immunoglobulin (IVIG) is commonly used to treat humoral primary immunodeficiency diseases (PIDs), but about one-third of patients experience adverse reactions, including kidney issues.
- A study conducted on patients receiving IVIG at a specialized clinic in Mexico City revealed that 51.4% of participants showed signs of kidney damage, particularly those who had been treated for over 5 years.
- The findings highlight the importance of regular kidney function evaluations for these patients and suggest using sugar-free immunoglobulin to mitigate risks of chronic kidney disease (CKD).
Background: Chronic spontaneous urticaria (CSU) is linked to thyroid disease in up to 54%, with predominance of hypothyroidism.
Objective: To describe the impairments of the thyroid function in patients with CSU in a third level of care.
Methods: A cross-sectional, observational, and descriptive study in which we have included men and women over 18-year-old with CSU; in which TSH and free T4 were quantified.
Background: Common variable immunodeficiency (CVID) is the most common primary symptomatic humoral immunodeficiency in adults. Antibody deficiency entails higher susceptibility to sinopulmonary infections and bronchiectasis formation, which is related to increased mortality. Scales have been established to assess the degree of severity of bronchiectasis in order to predict outcomes such as mortality, exacerbations and hospitalizations.
View Article and Find Full Text PDFCommon variable immunodeficiency (CVID) is the most common symptomatic immunodeficiency in adulthood. CVID diagnosis is by exclusion and should be considered in patients of any age who have hypogammaglobulinemia of unknown origin. Numerous patients with CVID show alterations in the development of B lymphocytes, both in plasma cells and memory cells.
View Article and Find Full Text PDFArticle Synopsis
- Latex-fruit syndrome (LFS) is an allergic condition where individuals react to both latex and certain plants, with papaya being a significant allergen due to its protein similarities with latex.
- A study involving 11 patients with LPS revealed that the majority were females with a history of severe allergic reactions to papaya, and many had additional allergies or medical conditions.
- The findings highlight the increased risk of anaphylaxis for latex-allergic individuals exposed to papaya, emphasizing the need for education on managing such allergic reactions effectively.
Article Synopsis
- - Primary immunodeficiencies (PIDs) are rare genetic disorders that impact the immune system, with Common Variable Immunodeficiency (CVID) being the most prevalent form in adults, affecting about 1 in 25,000 to 50,000 people and often taking 6-7 years to diagnose.
- - CVID presents with various clinical manifestations, including infections, autoimmune disorders, and gastrointestinal issues, and may be diagnosed even in asymptomatic individuals; however, secondary causes of low immunoglobulin levels must be excluded.
- - Patients with CVID may face multiple complications, necessitating careful monitoring for conditions like lymphoproliferative disease and lung issues, although there's no established guideline on the frequency of evaluations,
Article Synopsis
- Primary immunodeficiencies (PID) often affect the immune system, with humoral deficiencies being the most common type, including conditions like selective IgA deficiency and common variable immunodeficiency (CVID).
- A study analyzed 35 adults with humoral PID, finding 88.5% had CVID and highlighting a significant delay in diagnosis and various associated health issues.
- The research concluded that CVID is the predominant form of humoral PID in men, with gastrointestinal disorders, particularly intestinal functional disorders, being common among these patients.
Corticosteroid hypersensitivity is a complex phenomenon in which many factors interact, such as idiosyncrasy, intolerance or allergic reactions. The prevalence of immediate hypersensitivity reactions to corticosteroids is 0.2%-0.
View Article and Find Full Text PDFThe diagnosis of food allergy requires a proper anamnesis and diagnostic testing with skin prick tests with fresh foods and/or standardized allergen, or specific IgE tests. The risk of systemic reactions is of 15-23 per 100,000 skin tests performed by prick method, specifically anaphylaxis at 0.02%.
View Article and Find Full Text PDFBackground: Common variable immunodeficiency is a primary immunodeficiency, in which from 70 to 80 % of patients have tumors and 25 % of cases are associated with autoimmune diseases. Common variable immunodeficiency patients have a higher incidence of neoplasms, with a risk 12-18 times higher than the general population. There are few cases of common variable immunodeficiency patients with leukemia.
View Article and Find Full Text PDFBackground: Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinemia. Its prevalence is 1:10000 to 1:50000 with the highest incidence in children, 6 to 10 years, and in adults around age 29. The association of CVID and bronchiectasis has a prevalence of 17-90%.
View Article and Find Full Text PDFBackground: Vitamin D regulates cellular activity, also it has effects on: innate and adaptive immunity, antimicrobial, anti-inflammatory and immunomodulatory functions. It has been suggested a possible association between vitamin D deficiency and increased risk and length of respiratory infections in patients with common variable immunodeficiency (CVID).
Methods: We conducted a descriptive study in patients with CVID.