Publications by authors named "Patricia Macanas"
Article Synopsis
- Gallbladder cancer (GBC) is a highly lethal cancer with low overall incidence but higher prevalence in specific regions like Chile; this study compares clinical and molecular features of GBC patients from Chile and the US.
- The study involved 260 patients, revealing a significantly higher rate of gallstones in the Chilean cohort and similar genetic alteration prevalence between the two groups, with overall alterations found in 14% of patients.
- Patients with GBC having genetic alterations showed better overall survival rates, suggesting they may benefit from targeted therapies, highlighting the necessity for broader genomic analysis in regions with high GBC rates.
Aims: Equilibrative nucleoside transporter 1 (ENT1) is the major transporter of the chemotherapeutic drug gemcitabine, the current therapy for advanced gallbladder cancer (GBC). ENT1 expression has been proposed as a predictive marker for gemcitabine-treated pancreatic cancer patients. The aim of study was to explore the value of ENT1 measurement in chemotherapy-naïve patients with advanced GBC.
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