Quantitative and qualitative spectral domain optical coherence tomography analysis of subretinal deposits in patients with acute central serous retinopathy.

Purpose: To perform qualitative and quantitative analyses of subretinal protein deposits (PDs), seen in acute central serous retinopathy (CSR) patients, using high-resolution spectral domain optical coherence tomography (SD-OCT), in order to investigate whether the present PDs have any significant impact on best corrected visual acuity (BCVA).

Methods: Patients diagnosed with acute CSR were included. Using SD-OCT, the following distances/heights were measured: central total retinal thickness, central neurosensory retinal thickness, the vertical and horizontal length of subfoveal subretinal fluid and subfoveal thickness of the PD layer, if present and could be measured.

Abnormal fixation in individuals with age-related macular degeneration when viewing an image of a face.

Purpose: It has been reported that patients with macular disease have difficulties with face perception. Some of this difficulty may be caused by the sensory and perceptual consequences of using peripheral retina. However, strong correlations have not always been found between performance on face tasks and clinical measure of function.

The physics and psychophysics of microperimetry.

Purpose: To assess the influences of stimulus parameters (physics) on measures of visual field sensitivity (psychophysics).

Methods: Subjects' thresholds were measured on three different clinically available perimeters: the Humphrey Field Analyzer (HFA), the Nidek MP1 (MP1), and the Opko OCT/SLO (OSLO). On all machines, visual field testing was done with a 10-2 spatial distribution of test points, using Goldmann Size III and Size I stimuli, with a presentation time of 200 ms, and using a 4-2 threshold algorithm.

Initial report of quantification of retinal blood flow velocity in normal human subjects using the Retinal Functional Imager (RFI).

The Retinal Functional Imager (RFI) is a novel method for assessing retinal blood flow (RBF) velocity. The purpose of this study was to evaluate RBF velocities in normal human retinas using the RFI. RBF velocity measurements were performed in normal subjects using the RFI (Optical Imaging Ltd.

Drusen characteristics revealed by spectral-domain optical coherence tomography and their corresponding fundus autofluorescence appearance in dry age-related macular degeneration.

Purpose: To analyze the relationship between drusen morphology revealed by spectral-domain optical coherence tomography (SD-OCT) and corresponding fundus autofluorescence (FAF) features of the same drusen using the Heidelberg Retina Angiograph 2 (HRA2), in patients with dry age-related macular degeneration (AMD).

Methods: Dry AMD patients were imaged with SD-OCT and HRA2 on the same day. SD-OCT B scans were then precisely overlaid onto the HRA2 images, and the SD-OCT morphological characteristics of the drusen were correlated with the corresponding FAF appearance.

Qualitative spectral OCT/SLO analysis of drusen change in dry age-related macular degeneration patients treated with Copaxone.

Purpose: High-resolution spectral domain OCT/SLO (SD-OCT) has become an increasingly useful tool for differentiating drusen morphologic parameters such as shape, internal reflectivity, homogeneity, and presence of overlying hyperreflective foci. Our purpose was to evaluate which types of drusen may respond to Copaxone (glatiramer acetate) treatment of dry age-related macular degeneration (AMD) patients by shrinking or disappearing.

Methods: A prospective and interventional clinical trial of patients with dry AMD who received subcutaneous treatment with Copaxone or sham injections was conducted.

Inner segment-outer segment junctional layer integrity and corresponding retinal sensitivity in dry and wet forms of age-related macular degeneration.

Purpose: To investigate a relationship between the inner segment-outer segment (IS-OS) junctional layer integrity and the overlying retinal sensitivity assessed by Spectral OCT/SLO (spectral-domain optical coherence tomography) and microperimetry testing in patients with dry and wet forms of age-related macular degeneration (AMD).

Methods: Spectral-domain optical coherence tomography examination and microperimetry testing were performed in 55 eyes of 43 consecutive patients with AMD. Microperimetry maps were registered onto three-dimensional retinal topography maps, and point-to-point analysis of correlation between microperimetric retinal sensitivities and corresponding status of the underlying IS-OS junctional layer was performed.

Acquired senile retinoschisis of the peripheral retina imaged by spectral domain optical coherence tomography: a case report.

Purpose: We report spectral domain optical coherence tomography findings of the peripheral retina in a patient with senile (acquired) retinoschisis.

Methods: This is an observational case report. Spectral domain optical coherence tomography was performed to image the peripheral retina at the area of retinoschisis in a 70-year-old man with bilateral inferonasal elevated peripheral retinal lesions.

Combined three-dimensional spectral OCT/SLO topography and Microperimetry: steps toward achieving functional spectral OCT/SLO.

Aims: To investigate the combination of 3D optical coherence tomography (OCT) retinal thickness measurements and superimposed scanning laser ophthalmoscopy (SLO) microperimetry obtained using a Spectral OCT/SLO and to test the correlation between retinal thickness and retinal sensitivity in retinal diseases grouped according to anatomic locations.

Methods: Patients with various retinal diseases and subjects with normal fundi underwent microperimetry testing and imaging with the Spectral OCT/SLO. Based on the Spectral OCT/SLO findings, the participants were divided into 4 groups: patients with retinal thickening due to the outer retina pathology (group I); patients with retinal thickening due to the cystic changes observed in the inner retina (group II); patients with macular neurosensory retina thinning associated with geographic atrophy or underlying subretinal cicatricial changes (group III), and subjects with unremarkable fundus appearance and normal appearing retina on Spectral OCT/SLO (group IV).

Correlation between retina blood flow velocity assessed by retinal function imager and retina thickness estimated by scanning laser ophthalmoscopy/optical coherence tomography.

Purpose: The purpose of this study was to evaluate the correlation between the retinal blood flow (RBF) assessed by the retinal functional imager (RFI) and central macular thickness/volume assessed by a spectral scanning laser ophthalmoscopy/optical coherence tomography (SLO-OCT) system.

Methods: Seventeen eyes of 14 consecutive patients with various ocular diseases were examined. Retinal blood circulation characteristics were measured using the RFI.

Imaging through opaque corneas using anterior segment optical coherence tomography.

Background And Objective: To investigate the capability of the prototype AC Cornea OCT (Ophthalmic Technologies Inc., Toronto, Ontario, Canada) for imaging eyes with opaque corneas.

Patients And Methods: More than 50 eyes of patients were included in the study.

Surface rendering of 3D ultrasound images in ophthalmology.

Surface rendering of three-dimensional ultrasound images is a novel way of imaging ophthalmic pathologies in vivo. The authors have evaluated surface rendering of three-dimensional ultrasound images in selected cases of opthalmic disease.

Optic nerve measurements by 3D ultrasound-based coronal "C-scan" imaging.

Twenty-three normal eyes were examined with the Intensity Profiling technique of 3D I-Scan and 52 normal eyes with the Automated technique of OTI-Scan 1000 ultrasound systems (Ophthalmic Technologies Inc., Toronto, Ontario, Canada). With the eye looking straight, the probe was applied on the temporal sclera.

Wide-field handheld high frequency ultrasonography using a variable high frequency ultrasound system.

Wide-field handheld high frequency ultrasonography using a variable high frequency ultrasound system is an imaging modality in the frequency range of 35 to 50 MHz. Using a water bath immersion technique, high-resolution digital movies obtained from a variety of anterior segment ocular conditions were particularly helpful in establishing the diagnosis in each case. Images taken with the wide-field limbus-to-limbus mode provided a comprehensive picture of large and extensive lesions, whereas the focal mode was for small to medium lesions or specific areas of interest.