Publications by authors named "Patricia Luengo"
Article Synopsis
- - Medullary thyroid carcinoma (MTC) is a rare cancer originating from the thyroid's neuroendocrine C-cells, and a new two-tier grading system based on tumor characteristics like proliferation and necrosis has been established to help predict patient outcomes.
- - A transcriptomic analysis of 21 MTC samples revealed a significant upregulation of various genes in high-grade tumors, suggesting distinct molecular pathways involved in tumor aggressiveness, such as DNA damage repair and apoptosis.
- - The study found that DLL3 expression is correlated with poorer survival rates in MTC patients, particularly when DLL3 is overexpressed in at least 50% of tumor cells, indicating its potential as a biomarker for aggressive disease. *
Introduction/objectives: The use of non-occupational post-exposure prophylaxis (nPEP) emerges as a strategic intervention to reduce HIV infection risk following sexual encounters in our setting. Notwithstanding, there is a scarcity of contemporary data regarding adherence to this treatment, its effectiveness and tolerance. Our study aims to delve into these factors among individuals who have resorted to nPEP after high-risk sexual encounters.
View Article and Find Full Text PDFBackground: Post-operative hypoparathyroidism is the most frequent complication after total thyroidectomy. The identification of preoperative predictors could be helpful to identify patients at risk. This study aimed to evaluate the potential influence of preoperative PTH levels and their perioperative dynamics as a predictor of transient, protracted, and permanent post-operative hypoparathyroidism.
View Article and Find Full Text PDFIntroduction: Four-dimensional computerized tomography (4D-CT) offers a good sensitivity for the localization of the pathological gland responsible of primary hyperparathyroidism. The aim was to evaluate its results as a second line preoperative localization test after inconclusive or discordant results of usual preoperative studies.
Material And Methods: Observational retrospective study that included all patients intervened for primary hyperparathyroidism with 4D-CT scan as preoperative study, from 1st October 2016 to 1st October 2021, in a tertiary referral centre.
Background: Some patients with primary hyperparathyroidism (PHPT) have an elevated PTH that does not always correlate with high blood calcium levels. We aimed to compare the clinical presentation between normocalcaemic and hypercalcaemic forms using ionized calcium levels as an inclusion criterion.
Methods: We included all patients referred for surgery for PHPT between January 2015 and December 2017.