In vivo genotoxicity evaluation of a treated urban sewage sludge sample.

Tons of sludge is produced daily in sewage treatment plants of large cities, causing an enormous disposal problem. Because recycling has been proposed to mitigate the situation, the potential adverse health effects of the sludge should be verified before that policy is undertaken. The present study is a part of an assessment of oral toxicity in rats fed with sewer-treated sludge and aimed to contribute to its genotoxicity characterization.

Lack of DNA damage induced by fluoride on mouse lymphoma and human fibroblast cells by single cell gel (comet) assay.

Fluoride has widely been used in Dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury on genetic apparatus. Genotoxicity tests constitute an important part of cancer research for risk assessment of potential carcinogens.

Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells.

Objective: In the current study, the potential DNA damage associated with exposure to a number of antimicrobial endodontic compounds was assessed by the single cell gel (comet) assay in vitro.

Study Design: Chinese hamster ovary (CHO) cells were exposed to formocresol, paramonochlorophenol, calcium hydroxide, or chlorhexidine at final concentration ranging from 0.01% to 1%.