Publications by authors named "Patricia Lechner"
Background: Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation.
Objective: The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS.
Corticocortical functional interactions between the primary motor cortex (M1) and secondary motor areas, such as the dorsal (PMd) and ventral (PMv) premotor cortices and the supplementary motor area (SMA) are relevant for residual motor output after subcortical stroke. We hypothesized that the microstructural integrity of the underlying white matter tracts also plays a role in preserved motor output. Using diffusion-tensor imaging we aimed at (i) reconstructing individual probable intrahemispheric connections between M1 and the three secondary areas (PMd, PMv, SMA) and (ii) examining the extent to which the tract-related microstructural integrity correlates with residual motor output.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted on stroke patients to investigate how γ-aminobutyric acid-dependent intracortical inhibition (ICI) influences motor recovery after a stroke, specifically focusing on hand function over one year.
- The researchers tracked eleven patients' motor function and ICI, finding that higher ICI levels in the initial week post-stroke correlated with greater improvements in grip strength and finger-tapping speed.
- The conclusions suggest that enhanced ICI shortly after a stroke may be an important brain mechanism that helps drive recovery of hand motor skills.