Publications by authors named "Patricia Le Nahenec-Martel"
Article Synopsis
- Researchers developed new cadiolide analogues through a one-pot multi-component synthesis to enhance antibacterial properties.
- These new compounds were tested against standard and antibiotic-resistant bacterial strains and showed promising efficacy, with minimum inhibitory concentrations (MICs) of 2 μg/mL.
- Notably, some of the most effective compounds include an indole group or a modified lactone, and they demonstrated low toxicity towards keratinocyte cells, suggesting potential for safe application in human health.
A brief literature survey reveals that metal-free ligation such as the maleimide-based cycloaddition with electron-rich (hetero)dienes is a widespread tool for the assembly of (bio)molecular systems with applications in biotechnology, materials science, polymers and bio-organic chemistry. Despite their everyday use, only scattered data about their kinetics as well as the stabilities of corresponding products under physiological conditions, are accessible. These key parameters are yet, of paramount importance to ensure the rapid and effective preparation of stable compounds.
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