Publications by authors named "Patricia Kovats"
Int J Mol Sci
October 2024
Article Synopsis
- Autoimmune hepatitis (AIH) is a chronic liver disease treated with steroids and the thiopurine drug azathioprine (AZA), which is metabolized into active forms like 6-thioguanine (6-TG) and 6-methyl-mercaptopurine (6-MMP).
- This study focused on creating a quick and effective ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) method to analyze levels of 6-TG and 6-MMP in blood samples from AIH patients.
- The new method was validated following EMA guidelines and proved to be accurate and precise for monitoring these important metabolites, facilitating better treatment management for patients.
Article Synopsis
- - The R-LIVER registry, initiated by the European Reference Network on Hepatological Diseases, analyzed the presentation and outcomes of autoimmune hepatitis (AIH) in 231 patients across six European centers over a year.
- - After 6 months, 50% of patients achieved complete biochemical response (CBR), with a rise to 63% by the 12-month mark, but only 27% managed to achieve this without steroids during the first year.
- - Results indicate significant variability in AIH treatment, with many patients experiencing treatment changes due to intolerance, and highlight the need for improved strategies given the low CBR rates and challenges in steroid withdrawal.
World J Gastroenterol
November 2023
Article Synopsis
- Defective neutrophil regulation in inflammatory bowel disease (IBD) can lead to damage in the intestinal barrier, causing increased inflammation and pathogen accumulation, potentially influenced by the loss of tolerance to chitinase 3-like 1 (CHI3L1).
- The study aims to analyze the predictive value of anti-CHI3L1 autoantibodies (aCHI3L1) Ig subtypes in understanding disease progress, therapy choices, and patient outcomes in IBD.
- Results indicate a higher prevalence of IgA antibodies in Crohn's disease compared to ulcerative colitis and healthy controls, with secretory IgA also being significantly more common in both disease groups than in healthy individuals.
