Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors.

Purpose: The purpose of this study was to investigate the albumin-binding compound In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors.

Methods: In-C4-DTPA was injected in healthy nude mice for pharmacokinetic and biodistribution studies (10 min, 1, 6, 24, and 48 h,  = 4) and subsequently in tumor-bearing mice for single-photon emission computed tomography/X-ray-computed tomography (SPECT/CT) imaging studies. Four different human tumor xenograft models (LXFL529, OVXF899, MAXFTN401, and CXF2081) were implanted subcutaneously unilaterally or bilaterally ( = 4-8).