Publications by authors named "Patricia Garbayo-Salmons"
Article Synopsis
- * Genetic studies have identified issues with Notch signaling and inflammasome function in HS, while syndromic HS is linked to mutations in certain autoinflammatory syndromes like PAPA and PASH.
- * Research in proteomics and microbiome profiling highlights inflammatory pathways and a disturbed balance of bacteria in HS lesions, while metabolomic studies reveal imbalances in tryptophan and lipid metabolism, indicating potential bacterial involvement; however, establishing strong links across these
Article Synopsis
- The research evaluates the effectiveness and safety of bimekizumab for treating hidradenitis suppurativa in real-world clinical settings.
- Significant improvements were observed in key activity scores and patient-reported outcomes after 16 weeks, with all results showing a strong statistical significance (p < 0.001).
- Bimekizumab was well-tolerated with no reported discontinuations or new safety issues, reaffirming its favorable safety profile previously seen in phase 3 clinical trials.
Real-world adalimumab survival and discontinuation factors in hidradenitis suppurativa.
J Eur Acad Dermatol Venereol
January 2025
Article Synopsis
- - The study analyzed the survival rate and interruption risks of adalimumab (ADA) treatment in 539 adult patients with hidradenitis suppurativa (HS), providing insights before and after the COVID-19 pandemic.
- - Findings revealed that about 39.92% of patients interrupted ADA, with the main reasons being inefficacy (51.69%) and adverse effects (21.35%); ADA showed a median overall drug survival of 56.2 months.
- - Factors like female gender, prolonged HS diagnosis, and higher HS severity correlated with decreased ADA survival, while post-pandemic trends included younger patients starting treatment at a lower HS stage.
Case Report: Localized bullous pemphigoid induced by local triggers: a case series and a proposal for diagnostic criteria based on a literature review.
Front Immunol
June 2023
Article Synopsis
- Localized bullous pemphigoid (LBP) is a rare skin condition affecting specific body areas, often triggered by local factors in patients with pre-existing antibodies against the basement membrane.
- A study of 7 patients showed various local triggers such as surgery and burns, and introduced diagnostic criteria based on the findings and existing guidelines.
- Follow-up revealed that 3 patients progressed to generalized bullous pemphigoid, with many LBP cases linked to prior injuries, particularly affecting older women and frequently involving the lower limbs.
Cutaneous neoplasms from different cell types can exist within the same lesion. These can be classified into four subtypes which are collision tumour, combined tumour, colonization and biphenotypic tumour. The presence of a melanoma component in these tumours is very rare.
View Article and Find Full Text PDFObjectives: Calcium depositions are frequent in multiple inflammatory dermatosis, they can be explored by ultrasound (US) but the patterns of these depositions have not yet been described. The aim of this study is to describe different patterns of calcium deposition in inflammatory dermatoses.
Methods: The clinical and US data of 58 patients from 7 different centers with inflammatory dermatosis showing ultrasonography-detected calcium depositions was retrospectively reviewed.
Hidradenitis suppurativa (HS) involving the vulva is seldom reported in the gynecological or dermatological literature. The aim of this study was to describe the clinical characteristics of HS with vulvar affectation (VHS) and to compare it with patients without vulvar involvement. A cross-sectional study was conducted in a tertiary academic referral centre in Spain from May 1, 2015 to October 1, 2019.
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