Publications by authors named "Patricia Flores-Ahlschwede"
Objective: To determine the effects of transfusion of Rhodococcus equi hyperimmune plasma (REHIP) on serum concentrations of complement component 1q (C1q) and to examine the association of serum C1q and anti-rhodococcal antibodies of newborn foals with subsequent development of rhodococcal pneumonia.
Animals/samples: Foals (n = 205) from 2 Thoroughbred breeding farms in New York transfused with REHIP between January 1, 2022, and December 1, 2022.
Procedures: Blood was collected immediately before transfusion with REHIP and again from the contralateral vein immediately after transfusion.
Article Synopsis
- The study aimed to identify protective VP8 epitopes of equine rotavirus and test whether immunizing hens with synthetic peptides could produce effective neutralizing antibodies for foals.
- Researchers used white leghorn hens to generate high-titer anti-VP8 antibodies, which were then evaluated for their ability to neutralize the virus.
- The findings showed that administering hyperimmune egg yolk antibodies to foals with rotaviral diarrhea was safe and suggests potential for further study on their therapeutic benefits.
Article Synopsis
- - A study compared the effectiveness of two types of hyperimmune plasma—PNAG HIP and RE HIP—in protecting foals from R. equi pneumonia, showing that PNAG HIP had better lab results but had not been tested in real-world conditions.
- - In a controlled clinical trial involving 460 foals, both groups received transfusions of either RE HIP or PNAG HIP shortly after birth and were monitored for pneumonia symptoms.
- - The findings revealed no significant difference in pneumonia development between the two groups, indicating that PNAG HIP is not more effective than the established RE HIP for preventing the disease in foals.