Mandibular undifferentiated pleomorphic sarcoma: Molecular analysis of a primary cell population.

Background: Undifferentiated pleomorphic sarcomas are one of the most common subtypes of soft tissue sarcomas. These are aggressive mesenchymal tumors and are devoid of the major known biomarkers except vimentin. Our objective was to establish and characterize a primary cell population from a mandibular UPS specimen.

Features of peri-implantitis associated with luting cement extrusion: a histopathologic report in humans.

Objective: To describe and illustrate the histologic characteristics of luting cement-induced peri-implantitis in the posterior maxilla of a 56-year-old man.

Case Presentation: A dental implant inserted 6 years previously in the maxillary left first premolar region revealed pus and swelling. A periapical radiograph showed severe bone loss around the dental implant, and the presence of surrounding residual particles of luting cement.

GBR using cross-linked collagen membrane and a new highly purified bovine xenograft (Laddec) in horizontal ridge augmentation: Case report of clinical and histomorphometric analysis.

This case report presents the clinical and histologic evaluation of the application of a cross-linked collagen membrane and a new highly purified bovine xenograft with type 1 collagen fiber preservation (Laddec) in mandibular horizontal ridge augmentation on a 50-year-old woman. Significant bone volume was achieved to restore severe bone defect in order to place two implants. Histomorphometric analysis of a bone core at the augmented site, at 6 months, showed new bone formation with bone substitute particles integrated to new viable bone.

Establishment and characterization of a primary calcifying epithelial odontogenic tumor cell population.

Unlabelled: Calcifying epithelial odontogenic tumors (CEOTs) are rare neoplasms derived from dental tissue with the unique characteristic of calcifying amyloid-like material.

Objectives: To establish primary CEOT epithelial-derived cell populations, investigate the expression of enamel matrix proteins (EMPs), and identify potential ameloblastin (AMBN) and patched 1 (PTCH1) gene alterations.

Materials And Methods: A 28-year-old patient with a lesion of the posterior maxilla, radiographically characterized by a radiolucency with well-defined borders containing mixed radiopacities, agreed to participate with informed consent.

Targeting the sonic hedgehog pathway in keratocystic odontogenic tumor.

Keratocystic odontogenic tumors (KCOT) may occur sporadically or associated with the nevoid basal cell carcinoma syndrome. It is a benign aggressive tumor of odontogenic epithelial origin with a high rate of recurrence. A primary human keratocystic odontogenic tumor cell population, KCOT-1, has been established from a tumor explant culture.

Physical effects of sodium hypochlorite on bone: an ex vivo study.

Introduction: Sodium hypochlorite (NaOCl) accidents during endodontic therapy require accurate and prompt action. Understanding the physical properties of bone and evaluating the resultant cell damage from NaOCl exposure could improve management of these accidents. This study assessed the physical and histologic properties of dog femurs exposed to NaOCl for a period of 30 minutes.

Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational status.

Merkel cell carcinoma is one of the most aggressive primary cutaneous malignancies. Because some Merkel cell carcinomas express the receptor tyrosine kinase KIT, we aimed to evaluate the correlation of KIT expression with the outcome and the presence of activating mutations in the KIT gene in Merkel cell carcinoma. A total of 49 tumors from 40 patients with a diagnosis of Merkel cell carcinoma were identified, of which 30 cases from 21 patients were used in the study.

Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: similar behavior to sporadic type?

Objective: The objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).

Study Design And Setting: We performed a cross-sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.

Lymphedematous fibroepithelial polyps of the penis associated with long-term condom catheter use: case report and review of the literature.

Lymphedematous fibroepithelial polyps of the penis are lesions that have only recently been described and are frequently associated with condom catheter use. We report an additional case of lymphedematous fibroepithelial polyps of the penis in association with long-term condom catheter use in a 36-year-old man. Local excision showed large polypoid nodules with compact orthohyperkeratosis and mild acanthosis.

Cystinosis, Fanconi syndrome, and odontogenic cysts.

Cystinosis is a multisystemic genetic storage disorder characterized by a mutation in the transporter system of cystine. The disease particularly affects the renal system by causing deposition of cystine crystals leading to, if untreated, Fanconi syndrome and end-stage renal disease. This disease also affects the ocular system, central nervous system, endocrine system, hepatobiliary system, and musculoskeletal system.

Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor.

Ameloblastoma is a benign, locally aggressive epithelial odontogenic tumor that has the potential to become malignant and produce metastasis to distant sites such as lungs and kidneys. The histologic presentation can be, in some instances, mistaken for keratocystic odontogenic tumor (KCOT) (formerly known as odontogenic keratocyst). The expression of calretinin [calbindin2 (CALB2)] was investigated on both ameloblastoma and KCOT.