Dynamic elementomics of single-cell ICP-MS-derived signals in normal and calcium pump PMCA4-deficient mouse epididymal sperm during capacitation.

Currently, clinical analysis of male infertility mainly relies on parameters of semen and sperm cells. However, the high diagnostic failure rates indicate that the current assessment methods are not sufficient and a new approach to evaluating sperm function still needs to be developed. Here we explored the feasibility of single-cell inductively coupled plasma mass spectrometry (sc-ICP-MS)-derived profiles to determine the elemental characteristics in viable capacitated sperm under normal and deficient conditions.

Invasive mucinous carcinoma of the breast.

Mucinous carcinoma of the breast is one of the rarer forms of intramammary cancer, often presenting as a lobulated, fairly well circumscribed mass on mammography, sonography, and gadolinium-enhanced magnetic resonance imaging. It accounts for 1% to 7% of all breast cancers and generally carries a better prognosis than other types of malignant breast cancers. Metastatic disease occurs at a lower frequency than in other types of invasive carcinoma.

Breast fibromatosis mimicking breast carcinoma.

Fibromatosis arising from the breast, also referred to as desmoid tumor, aggressive fibromatosis, or low-grade fibrosarcoma, is a rare benign entity, accounting for only 0.2% of all breast tumors. Associations with familial multicentric fibromatosis and trauma, including that resulting from surgical intervention, have been reported.

The radial scar of the breast diagnosed at core needle biopsy.

The radial scar (RS) or complex sclerosing lesion (CSL) of the breast represents a management dilemma on diagnosis at breast core needle biopsy because of the risk of associated malignancy identified only upon surgical excision. To determine our experience, we retrospectively reviewed core needle biopsies performed at the Darlene G. Cass Breast Imaging Center from 2006 to 2011, identifying 67 patients with RS or CSL, and correlated histology at excisional biopsy with core biopsy results.

Digital and screen-film mammography: comparison of image acquisition and interpretation times.

Objective: The objective of our study was to compare acquisition times and interpretation times of screening examinations using screen-film mammography and soft-copy digital mammography.

Materials And Methods: Technologist study acquisition time from examination initiation to release of the screenee was measured for both screen-film and digital mammography (100 cases each) in routine clinical practice. The total interpretation time for screening mammography was also measured for 183 hard-copy screen-film cases and 181 soft-copy digital cases interpreted by a total of seven breast imaging radiologists, four experienced breast imagers, and three breast imaging fellows.