Hepatoprotective and Anti-Inflammatory Activities of the (Mc Vaugh) Leaf Extract in Chronic Models.

Previous report described that CHCl:MeOH extract of leaves and pure compounds (moretenol, moretenyl acetate, kaempferol-3,7-dimethyl ether, and 5-hydroxy-7-3',4'-trimethoxyflavanone) showed important topical and systemic anti-inflammatory activity in acute model, as well as antimycobacterial and antiprotozoal activities. In this paper, we describe the hepatoprotective and anti-inflammatory effects of the CHCl:MeOH extract in chronic model and the isolation of additional compounds (moretenone and lupeol acetate). The hepatoprotective activity was determined at 39 days using Balb/c mice with liver damage induced with an antitubercular drug (RIF/INH/PZA).