Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke.

Activated protein C (APC), a protease with anticoagulant and cytoprotective activities, protects neurons and cerebrovascular endothelium from ischemic injury. A recombinant APC, drotrecogin alfa (activated) (DrotAA) (Xigris®), was approved by the Food and Drug Administration for the treatment of sepsis; however, serious bleeding was a dose-limiting side effect. A modified APC, containing 405 amino acid residues, 3K3A-APC, was designed to possess significantly reduced anticoagulant activity ( < 10 %) while maintaining full cytoprotective properties.

Experiential leadership training for pediatric chief residents: impact on individuals and organizations.

Background: The past decade has seen a proliferation of leadership training programs for physicians that teach skills outside the graduate medical education curriculum.

Objective: To determine the perceived value and impact of an experiential leadership training program for pediatric chief residents on the chief residents and on their programs and institutions.

Methods: The authors conducted a retrospective study.

An assessment of user acceptance and satisfaction with the tobacco use cessation automated clinical practice guideline.

Objective: To describe user acceptance of and satisfaction with the Tobacco Use Cessation (TUC) Automated Clinical Practice Guideline (ACPG) at the Henry Ford Health System.

Study Design: A previous investigation assessed compliance with the 5 As (ask, advise, assess, assist, and arrange) of the TUC ACPG across 3 study arms. This article describes user satisfaction with the TUC ACPG after implementation.

Implementation of an obstetrics EMR module: overcoming user dissatisfaction.

To improve quality and efficiency, Henry Ford Health System developed and implemented a new obstetrics application that displays pertinent clinical practice guideline information and standardizes documentation. The initial application included an overview of the patient's vital sign history, a structured note appropriate for each visit and patient educational materials. Despite involvement by clinician subject-matter experts in its design, many clinicians were dissatisfied with the initial application, noting both performance and functionality issues.

Effects of the tobacco use cessation automated clinical practice guideline.

Objective: To evaluate the effects of the Tobacco Use Cessation (TUC) Automated Clinical Practice Guideline (ACPG) (a variation of the US Department of Health and Human Services Clinical Practice Guideline on Treating Tobacco Use and Dependence) on guideline adherence in a multisite health system.

Study Design: The study used a pre-post cross-sectional design. Paneled patients were enrolled from 6 clinics, including 2 control clinics (arm 1), 2 control clinics that received a check-in screen only (the check-in screen provided a simplified method for entering patient vital signs into the electronic medical record) (arm 2), and 2 clinics that received the TUC intervention (arm 3).