Publications by authors named "Patricia Clark"

Background: As the number of programs aimed at preventing fragility fractures and mitigating the phenomenon of cascade fractures is increasing worldwide, so it is necessary to evaluate the effectiveness of such programs to seek their feasible implementation at regional and global levels.

Aims: This paper aims to provide an overview focusing on the incidence of secondary fractures after the implementation of any type of fracture liaison service (FLS). To this end, a scoping review was conducted focusing on the identification of clinical evidence reported in systematic reviews of the medical literature in this area.

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In the 1970s, we learned breast conservation therapy (BCT) was not inferior to mastectomy. Early BCT methods could result in deformities that were unacceptable to patients and to their surgeons. By the 1990s, surgeons began to apply the principles of plastic surgery to improve outcomes.

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Introduction: Vitamin D deficiency is associated with bone metabolism and immune disorders. Radiation's seasonal variation affects vitamin D status more at the poles. In Mexico, near the equator, there have been reports of 10-20% vitamin D deficiency in children.

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  • The study investigates the acceptance of osteoporosis medication among postmenopausal women across nine countries, focusing on how various factors like age and fracture history influence this willingness.
  • Findings reveal that 79.2% of participants accepted treatment at fracture probabilities equal to or below the recommended threshold, highlighting a potential gap in fracture risk communication.
  • Higher numeric literacy was linked to a greater willingness to accept treatment compared to those with lower literacy levels, suggesting that improving patient understanding of risk could enhance treatment acceptance.
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Osteoporosis (OP) is a chronic disease that affects older adults' quality of life, with fragility fractures (FF) being its most significant consequence due to their impact on healthcare systems in terms of morbidity, and economic and caregiving burden. FF are defined as fractures resulting from low-energy trauma, defined as falls from a standing height or less, and are usually considered osteoporotic (1). World demographic projections warn of a significant increase in adults aged 65 and older by 2050.

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Synonymous codons were originally viewed as interchangeable, with no phenotypic consequences. However, substantial evidence has now demonstrated that synonymous substitutions can perturb a variety of gene expression and protein homeostasis mechanisms, including translational efficiency, translational fidelity, and cotranslational folding of the encoded protein. To date, most studies of synonymous codon-derived perturbations have focused on effects within a single gene.

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  • * The authors advocate for keeping ethnic and race-specific FRAX models in the US, suggesting they should be based on updated data related to fracture and death risks.
  • * The position opposing fixed bone mineral density thresholds is supported by the International Osteoporosis Foundation (IOF) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), emphasizing the need for equity in fracture risk assessment.
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Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrophobic content typical of foldable proteins, behave nearly as self-avoiding random walks (SARWs) under physiological conditions. Here, we tested how temperature and ionic conditions influence the dimensions of the N-terminal domain of pertactin (PNt), an IDP with an amino acid composition typical of folded proteins. While PNt contracts somewhat with temperature, it nevertheless remains expanded over 10-58°C, with a Flory exponent, ν, >0.

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Amino acid substitutions (AASs) alter proteins from their genome-expected sequences. Accumulation of substitutions in proteins underlies numerous diseases and antibiotic mechanisms. Accurate global detection of AASs and their frequencies is crucial for understanding these mechanisms.

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Unlabelled: This study, characterizing the incidence of hip fractures in Mexico, showed not only that the crude number of fractures has increased, but also there has been a decrease in fracture rates. Nonetheless, as the population ages in the coming decades, the current declines rate of could be expected to reverse.

Purpose: This study is to examine the incidence, rates, and time trends of hip fractures from 2006 to 2019 in Mexico.

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  • Lumpectomy and mastectomy have similar survival rates for breast cancer patients, but incomplete tumor removal indicated by positive lumpectomy margins can lead to local recurrence and increased mortality, often requiring a second surgery.
  • A clinical trial was conducted to determine the effectiveness of pegulicianine fluorescence-guided surgery (pFGS) in identifying cancerous margins during lumpectomy for various breast cancer stages, where patients were randomly assigned to pFGS or control groups to evaluate margin status.
  • Results showed that pFGS successfully identified residual tumors in some cases, avoiding second surgeries for some patients with positive margins; however, the overall sensitivity of pFGS was lower than hoped despite meeting specificity and successfully removing some remaining cancer.
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The rate of protein synthesis is slower than many folding reactions and varies depending on the synonymous codons encoding the protein sequence. Synonymous codon substitutions thus have the potential to regulate cotranslational protein folding mechanisms, and a growing number of proteins have been identified with folding mechanisms sensitive to codon usage. Typically, these proteins have complex folding pathways and kinetically stable native structures.

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Background: Rheumatoid arthritis is a highly prevalent disease. Patients undergo various medical and pharmacological treatments, which have an economic impact on hospitals. The aim of this study was to estimate the direct economic costs of Mexican Social Security Institute (IMSS) resources used to provide healthcare to adult patients with rheumatoid arthritis in 2016-2017.

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Background: Despite family carepartners of individuals post-stroke experiencing high levels of strain and reduced quality of life, stroke rehabilitation interventions rarely address carepartner well-being or offer training to support their engagement in therapeutic activities. Our group has developed creative intervention approaches to support families during stroke recovery, thereby improving physical and psychosocial outcomes for both carepartners and stroke survivors. The purpose of this study is to test the feasibility of an adapted, home-based intervention (Carepartner Collaborative Integrative Therapy for Gait-CARE-CITE-Gait) designed to facilitate positive carepartner involvement during home-based training targeting gait and mobility.

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Article Synopsis
  • - Patients want information about their fracture risk, but only a little over half have received it, according to the RICO study.
  • - The study involved structured interviews with 332 women at risk of fractures from multiple countries and found that most preferred visual tools for understanding their risk.
  • - Nearly all participants expressed the desire for improved discussions with healthcare professionals about their fracture risk and consequences, highlighting a communication gap in healthcare.
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Introduction: Given the increasing incidence of chronic degenerative diseases related to changes in tissues, the availability of diagnostic tools with greater accuracy in the estimation of body composition (BC) has become necessary. Interpreting the BC values of individuals requires reference data obtained from a healthy population with the same ethnicity, to identify individuals at risk for the development of negative health outcomes.

Objective: Generate reference values (RV) of body composition (BC) for Mexican children and adolescents.

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Purpose: The Area Deprivation Index (ADI) measures the relative disadvantage of an individual or social network using US Census indicators. Although a strong re-hospitalization predictor, ADI has not been routinely incorporated into rehabilitation research. The purposes of this paper are to examine the use of ADI related to study recruitment, association with carepartner psychosocial factors, and recruitment strategies to increase participant diversity.

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Health care clinicians, educators, and students who plan and implement quality improvement (QI) projects must know reporting guidelines for successful project planning and publication. We aimed to identify QI guidelines, which authors can locate, and highlight how best to use them for manuscript preparation. We also address guidelines for educational QI projects.

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Background: Virtual mock interviews were offered to students to improve job interviewing skills. This educational quality improvement project aimed to use virtual mock interviews to increase student preparedness and confidence, and reduce anxiety related to professional interviews.

Method: Health professions students ( = 19) participated in the mock interviews conducted and recorded through a web-based meeting.

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Mothers of school-aged children ages 3 to 17 years with developmental disabilities (DDs) commonly report sleep problems in their children associated with impaired maternal sleep. However, existing research relies heavily on mothers' self-reported sleep. This study aimed to determine the feasibility of objectively measuring child and mother sleep-wake patterns using actigraphy and videosomnography.

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Authors submitting a paper often receive an opportunity to revise and resubmit the paper. Authors may find addressing reviewers' comments challenging. We posit authors should welcome expert suggestions for revisions that strengthen the paper and develop a persuasive response if they disagree with the reviewer.

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Article Synopsis
  • Orofacial clefts (OFCs), including cleft lip and palate, are common birth defects affecting about 1 in 600 newborns globally, with their occurrence influenced by regional and ethnic variations.
  • This study focused on identifying risk factors for orofacial clefts in the Mexican population through interviews with patients and their families, analyzing sociodemographic, prenatal, and parental histories.
  • Key findings included significant associations between clefts and folic acid consumption and familial history, indicating that further research is necessary to uncover additional risk factors, especially genetic ones specific to the Mexican population.
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The purpose of a scientific journal is to communicate research results in a timely and reliable manner, and to provide its readers with new and relevant insights on different areas of knowledge.

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