The effect of sputtered calcium phosphate coatings of different crystallinity on osteoblast differentiation.

Background: Coating titanium implants with hydroxyapatite (HA) has been suggested to increase osseointegration by stimulating early osteoblast function. The goal of this study was to determine the extent to which the crystalline content of the HA surface affected osteoblast function in vitro.

Methods: Osteoblasts were isolated from fetal rat calvaria.