Publications by authors named "Patricia A Takeda"
The QuantumCor device for treating mitral regurgitation: an animal study.
Catheter Cardiovasc Interv
July 2009
Objectives: The mitral annular contraction achieved could help reduce mitral regurgitation (MR), and with appropriate modifications, be applied to human subjects providing a potentially effective percutaneous method of valve repair.
Background: MR is an important source of morbidity and is an independent predictor of mortality. A variety of percutaneous approaches are being developed to address this issue.
Despite a variety of pharmacological interventions to limit the regurgitant fraction, mitral regurgitation requires surgical intervention for definitive treatment. New nonsurgical techniques are being applied to treat mitral regurgitation. The mitral and tricuspid annuli are areas of dense collagen.
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- The study evaluated the durability and safety of the PS(3) system, a new device for treating functional mitral regurgitation, in sheep over a year.
- Eight healthy adult sheep were implanted with the PS(3) system, which successfully reduced the mitral annulus size and showed no signs of damage or complications during follow-ups.
- Results indicated that the PS(3) system was biocompatible with stable performance over time, and the forces on the device were minimal, suggesting it could be a durable treatment option.
Aims: Percutaneous edge-to-edge techniques and annuloplasty have been used to treat mitral regurgitation (MR). However, neither intervention can be performed reliably a second time and, with annuloplasty, a foreign body is left behind. The mitral and tricuspid annuli are areas of dense collagen (Fig.
View Article and Find Full Text PDFBackground: The septal-to-lateral (SL) mitral annular diameter is increased in functional mitral regurgitation (MR). We describe a novel percutaneous technique (the percutaneous septal sinus shortening system) that ameliorates functional MR in an ovine model.
Methods And Results: Sheep underwent rapid right ventricular pacing to obtain moderate to severe functional MR with SL enlargement.