Bilateral glomus tympanicum tumors: Human temporalbone study.

To describe human temporal bones with bilateral glomus tympanicum tumors. Patient is 83-year-old black female who no pulsatile tinnitus. The histopathologic characteristics of human temporal bones after death were setting Department of Otolaryngology of University of Minnesota in USA.

Neutrophil Extracellular Traps and Fibrin in Otitis Media: Analysis of Human and Chinchilla Temporal Bones.

Background: Bacterial resistance in acute otitis can result in bacterial persistence and biofilm formation, triggering chronic and recurrent infections.

Objective: To investigate the middle ear inflammatory response to bacterial infection in human and chinchilla temporal bones.

Design, Setting, And Participants: Six chinchillas underwent intrabullar inoculations with 0.

Histopathology of tympanic membranes from patients with ventilation tubes.

Objective: To evaluate the histopathologic changes in tympanic membranes (TMs) with ventilation tubes (VTs).

Methods: In this retrospective human temporal bone study our overall study group included 4 subgroups of TMs from deceased donors as follows: 24 with a history of VT insertion for chronic otitis media with effusion (COME-VT); 5 with a history of VT insertion for Meniere's disease (MD-VT); 33 without a history of VT insertion for chronic otitis media with effusion (COME); and 14 without a history of VT insertion for Meniere's disease (MD). We classified the extent of migration of the outer keratinized squamous epithelium onto the inner surface of TM perforations and noted the presence and location of tympanosclerosis, of atrophy, of perforation, and/or of cholesteatoma formation.

Deterioration of Vestibular Cells in Labyrinthitis.

Objective: To quantitatively assess the effect of serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans on vestibular hair cells, dark cells, and transitional cells.

Methods: We examined human temporal bone specimens with serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans, then compared them with age-matched control groups without labyrinthitis. We evaluated the density of type I and II vestibular hair cells, dark cells, and transitional cells in the peripheral sensorial organs.

A three-dimensional analysis of the endolymph drainage system in Ménière disease.

Objectives/hypothesis: To measure the volume of the endolymph drainage system in temporal bone specimens with Ménière disease, as compared with specimens with endolymphatic hydrops without vestibular symptoms and with nondiseased specimens STUDY DESIGN: Comparative human temporal bone analysis.

Methods: We generated three-dimensional models of the vestibular aqueduct, endolymphatic sinus and duct, and intratemporal portion of the endolymphatic sac and calculated the volume of those structures. We also measured the internal and external aperture of the vestibular aqueduct, as well as the opening (if present) of the utriculoendolymphatic (Bast's) valve and compared the measurements in our three study groups.

Pathologic Changes of the Peripheral Vestibular System Secondary to Chronic Otitis Media.

Objective: To evaluate the histopathologic changes of dark, transitional, and hair cells of the vestibular system in human temporal bones from patients with chronic otitis media.

Study Design: Comparative human temporal bone study.

Setting: Otopathology laboratory.

Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study.

Purpose: To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis.

Materials And Methods: We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis.

Results: The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P=0.

Histopathologic Evaluation of Vascular Findings in the Cochlea in Patients With Presbycusis.

Importance: Age-related changes in cochlear vessel wall thickness in human temporal bones have not been described previously.

Objectives: To compare thickness of the spiral modiolar artery and strial capillaries and to investigate strial atrophy and vessel loss in temporal bones with and without presbycusis.

Design, Setting, And Participants: This retrospective case-control study examined the autopsy reports of 1024 patients in the temporal bone collection at the University of Minnesota.

Effects of Intralabyrinthine Hemorrhage on the Cochlear Elements: A Human Temporal Bone Study.

Hypothesis: To compare histopathologic findings in the cochlea of human temporal bones with versus without intralabyrinthine hemorrhage.

Background: Hemorrhagic labyrinthitis can cause sensorineural damage, sudden hearing loss, and vertigo. Yet, to our knowledge, no studies have quantitatively described histopathologic effects of intralabyrinthine hemorrhage on the elements of the cochlea.

Quantitative assessment of vestibular otopathology in otosclerosis: A temporal bone study.

Objectives/hypothesis: To determine if peripheral vestibular otopathology is present in human temporal bones with otosclerosis.

Study Design: Comparative human temporal bone study.

Methods: Seventy-four human temporal bones from 46 subjects with otosclerosis (mean age of 61 ± 18 years) and 20 within histologically normal limits from 17 subjects (mean age of 59 ± 14 years) were included in this study.

Quantitative Vestibular Labyrinthine Otopathology in Temporal Bones with Vestibular Schwannoma.

Objective: Dizziness associated with vestibular schwannoma is usually ascribed to retrolabyrinthine mechanisms. The goal of this study was to determine if quantitative peripheral vestibular (labyrinthine) otopathology was present in a series of patients with vestibular schwannoma.

Study Design: Comparative human temporal bone study.

Volume of the epitympanum and blockage of the tympanic isthmus in chronic otitis media: a human temporal bone study.

Hypothesis: To compare the differences in the epitympanic bony volume and the area of the tympanic isthmus (TI) in human temporal bones (HTBs) with chronic otitis media (COM) having epitympanic involvement and those without COM.

Background: TI is crucial for mastoid and epitympanic ventilation. Previous studies demonstrated that the area of TI was related to the degree of HTBs pneumatization and that COM caused suppressed pneumatization of the middle ear, decreasing volume.

Pneumococcal PspA and PspC proteins: potential vaccine candidates for experimental otitis media.

Objective: Otitis media is the most commonly diagnosed disease in ambulatory care and Streptococcuspneumoniae continues to be the most common bacterial agent. Bacterial resistance to antibiotics underscores the need for better vaccines. Current pneumococcal conjugate vaccines are modestly protective against otitis media; however, limited serotype coverage and serotype replacement have led to the investigation of pneumococcal proteins as potential vaccine candidates.

Viability and virulence of pneumolysin, pneumococcal surface protein A, and pneumolysin/pneumococcal surface protein A mutants in the ear.

Importance: Understanding how pneumococcal proteins affect the pathology of the middle ear and inner ear is important for the development of new approaches to prevent otitis media and its complications.

Objectives: To determine the viability and virulence of Streptococcus pneumoniae mutants deficient in pneumolysin (Ply-) and pneumococcal surface protein A (PspA-) in the chinchilla middle ear.

Design: Bullae of chinchillas were inoculated bilaterally with wild-type (Wt), Ply-, PspA-, and Ply-/PspA- strains.

Inner ear changes in mucopolysaccharidosis type I/Hurler syndrome.

Objective: Mucopolysaccharidosis type I/Hurler syndrome is an autosomal recessive disease caused by a deficiency of α-L-iduronidase activity. Recurrent middle ear infections and hearing loss are common complications in Hurler syndrome. Although sensorineural and conductive components occur, the mechanism of sensorineural hearing loss has not been determined.

Peripheral vestibular system in Down syndrome: quantitative assessment of vestibular histopathology.

Objective: To evaluate the maturity of the peripheral vestibular system in Down syndrome by examining the number of Scarpa's ganglion cells and the density of vestibular hair cells.

Study Design: Case-control study using human temporal bones.

Setting: Tertiary academic center, otopathology laboratory.

Effect of apolactoferrin on experimental pneumococcal otitis media.

Objective: To find the effect of apolactoferrin administration on the middle and inner ears after experimentally induced pneumococcal otitis media.

Design: Histopathologic and morphometric analysis of the middle and inner ears.

Setting: University of Minnesota, Minneapolis.

Marrow-middle ear connections: a potential cause of otogenic meningitis.

Hypothesis: We hypothesize that the connections between the hematopoietic bone marrow and middle ear is a potential cause of childhood otogenic meningitis.

Background: Although it is known that there is a causal relationship between otitis media and bacterial meningitis, the relationship has never been satisfactorily established. Human fetal and infant temporal bones prepared for light microscopic evaluation revealed direct connections between the hematopoietic bone marrow and middle ear.

Posterior semicircular canal dehiscence: a histopathologic human temporal bone study.

Background: Posterior semicircular canal dehiscence has been shown to cause ear symptoms.

Objective: To evaluate the incidence of dehiscence of the posterior semicircular canal, thin bone overlying the posterior semicircular canal, and the normal development of the distance between the posterior semicircular canal and posterior cranial fossa.

Methods: The shortest distance between the posterior semicircular canal and posterior cranial fossa was measured in 1,051 adult human temporal bones (557 cases), and temporal bones with a distance less than 0.

Histopathological morphometric study of cochleosaccular dysplasia in Dalmatian dogs.

Objective: To analyze temporal bones of deaf Dalmatian dogs from 5 days after birth to adulthood to better understand the pathogenesis of cochleosaccular dysplasia.

Methods: This is an experimental animal histopathological temporal bone study that included two groups of temporal bones. Group I consisted of 41 temporal bones from deaf Dalmatian dogs and group II of 25 temporal bones from 15 "normal" aged-matched, hearing Black Labradors.

Cochlear changes in presbycusis with tinnitus.

Objectives: The pathophysiology of tinnitus is obscure and its treatment is therefore elusive. Significant progress in this field can only be achieved by determining the mechanisms of tinnitus generation, and thus, histopathologic findings of the cochlea in presbycusis with tinnitus become crucial. We revealed the histopathologic findings of the cochlea in subjects with presbycusis and tinnitus.

Pathologic correlations of otologic symptoms in acute lymphocytic leukemia.

Objectives: To assess the clinicopathologic correlations of otologic complaints in patients with acute lymphocytic leukemia.

Design: Otologic complaints and histologic findings were evaluated in 25 temporal bones of 13 acute lymphocytic leukemia patients.

Results: Nine patients had a history of otologic complaints, including hearing loss, otalgia, otorrhea, and vertigo in 5, 3, 3, and 2 patients, respectively.

Polyarteritis nodosa: a human temporal bone study.

Purpose: Polyarteritis nodosa is one of the common forms of vasculitis with multiorgan involvement. Hearing loss may be the presenting symptom of this disease. The aim of this histopathologic study was to evaluate temporal bone changes in polyarteritis nodosa and assess the correlation between otologic manifestations and histopathologic findings.

Cochlear pathology in human temporal bones with otitis media.

Conclusion: Middle and inner ear interactions in otitis media can lead to cochlear pathology. More severe pathological changes observed in the basal turn of the cochlea are consistent with prevalence of sensorineural hearing loss at higher frequencies in patients with otitis media.

Methods: Of 614 temporal bones with otitis media, 47 with chronic and 35 with purulent otitis media were selected following strict exclusion of subjects with a history of acoustic trauma, head trauma, ototoxic drugs, and other diseases affecting the cochlear labyrinth.

Effect of lipooligosaccharide mutations of Haemophilus influenzae on the middle and inner ears.

Objective: The purpose of this study was to determine the virulence of nontypeable Haemophilus influenzae 2019 (NTHi 2019) and its two lipooligosaccharide (LOS) mutant strains, B29 (gene htrB) and DK1 (gene rfaD), and compare their effect on the middle ear, round window membrane, and inner ear.

Results: Fifteen chinchillas were divided into three equal groups and their bullas inoculated bilaterally with 0.5 ml of 10(2)CFU/ml of parent NTHi 2019, B29 or DK1 mutant strains.