Publications by authors named "Patricia A Ortiz-Tello"
Article Synopsis
- The Caribbean has a mix of different people with unique histories, so scientists studied the genes of 330 individuals from various places, including both islands and mainland areas.
- They found that the Caribbean's native ancestry mainly comes from South American tribes, showing that people moved around a lot before Columbus arrived.
- Researchers also discovered that there were two waves of African migration to the Caribbean, one from the early slave trade and another from later deportations, and they noticed a special European ancestry specific to Latinos that has changed over time.
Jumonji C (JmjC) lysine demethylases (KDMs) are Fe(II)-dependent hydroxylases that catalyze the oxidative demethylation of methyllysine residues in histones and nonhistone proteins. These enzymes play vital roles in regulating cellular processes such as gene expression, cell cycle progression, and stem cell self-renewal and differentiation. Despite their biological importance, recombinant forms of JmjC KDMs generally display low enzymatic activity and have remained challenging to isolate in a highly active form.
View Article and Find Full Text PDFJMJD2A is a JmjC histone demethylase (HDM) that catalyzes the demethylation of di- and trimethylated Lys9 and Lys36 in histone H3 (H3K9me2/3 and H3K36me2/3). Here we present the crystal structures of the JMJD2A catalytic domain in complex with H3K9me3, H3K36me2 and H3K36me3 peptides. The structures reveal that histone substrates are recognized through a network of backbone hydrogen bonds and hydrophobic interactions that deposit the trimethyllysine into the active site.
View Article and Find Full Text PDF