Partial syntheses of aromatic amides: their anti-urease potential and docking studies.

The aromatic amide: ---coumaroyltyramine () was isolated for the first time from the stem bark of (Ulmaceae). Its four new derivatives (-) and previously reported diacetylated product () have been synthesized and characterized spectroscopically followed by their screening for anti-urease potential. The diacetylated product () was found to be the most potent inhibitor with an IC value of 19.

Zenkeramide: a new iso-benzofuranone propanamide and urease inhibitory constituents of Engl stem bark (Ulmaceae).

A new iso-benzofuranone propanamide: 3-(3-oxo-1, 3-dihydroisobenzofuran-1-yl) propanamide (zenkeramide) ( along with three known compounds: Trans-N-coumaroyltyramine (), β-Sitosterol () and sitosterol-3-D-glucopyranoside () were isolated from the ethyl acetate fraction of the stem-bark of Engl (Ulmaceae). The structure of the new compound was elucidated by extensive spectroscopic analysis. The compounds were examined for Urease Inhibitory Activity.

A new squalene derivative from L. (Solanaceae).

is an annual herb which has tremendous medicinal uses. The antioxidant activity of the whole plant extract of was investigated using DPPH radical scavenging activity. Purified compounds were isolated using column chromatography method.

Gakolanone: a new benzophenone derivative from Heckel stem-bark.

Gakolanone (3',5'-digeranyl-2',4',6',3-tetrahydroxybenzophenone; ), a novel benzophenone derivative was isolated from the hexane extract of Heckel stem-bark along with three known 3-8'' linked biflavonoids: 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (); 3'',4',5,5'',5''',7,7''-heptahydroxy-4-methoxy-3,8''-biflavanone () and 4',4''',5,5'',7,7''-hexahydroxy-3,8''-biflavanone () from the ethanol extract. The compounds were characterized primarily using 1 D and 2 D nuclear magnetic resonance spectroscopy and mass spectrometry and by comparing with literature. The compounds were subjected to alpha-amylase enzyme inhibitory assay using DNSA (3,5-dinitrosalicylic acid) reagent with acarbose used as the standard drug.

Two new prenylflavanones from Erythrina sigmoidea.

Two new prenylflavanones named sigmone and sigmotriol have been isolated from the stem bark of Erythrina sigmoidea along with two known constituents 8-(3"-methylbut-2"-enyl)-7,3',4'-trihydroxyflavanone and 7,3',4'-trihydroxyflavanone. Their structures were elucidated by spectroscopic methods.

bis-Sigmodiol: a new prenylflavanone dimer from Erythrina sigmoidea Hua (Fabaceae) of Nigeria.

A new prenylflavanone dimer named bis-sigmodiol was isolated from Erythrina sigmoidea, along with six known constituents isobavachin, lupiwighteone, orientanol A, ergosta-4, 6, 8 (14), 22-tetraen-3-one, lupenyl acetate, and p-hydroxybenzoic acid. These known constituents have not been reported so far from E. sigmoidea.

Phytochemical investigation, cytotoxicity and free radical scavenging activities of non-polar fractions of Acalypha hispida (leaves and twigs).

Free radicals are involved in the process of lipid peroxidation and play a cardinal role in numerous chronic diseases like cancer, coronary heart disease and ageing. Thus the ability to scavenge free radicals in order to minimize oxidative damage to living cells is very important. The hexane extract of (Burn F.

New phthalates from Phyllanthus muellerianus (Euphorbiaceae).

Species of the genus Phyllanthus are known for their medicinal values and many are explored phytochemically. Some of them produce phthalates which usually have antimicrobial properties. This paper deals with the phytochemical investigation on Phyllanthus muellerianus.