Canine hip dysplasia treated by juvenile pubic symphysiodesis. Part I: two year results of computed tomography and distraction index.

Objectives: To measure one and two year effects of juvenile pubic symphysiodesis (JPS) in puppies defined as 'at-risk' for canine hip dysplasia (CHD) using the following objective hip conformation criteria: Acetabular angle (AA), dorsal acetabular rim angle (DARA) and hip laxity (PennHIP© distraction index (DI).

Design: Controlled clinical case study.

Animals: Thirty-nine dysplastic puppies (six controls).

Canine hip dysplasia treated by juvenile pubic symphysiodesis. Part II: two year clinical results.

Objectives: To determine the clinical effects of juvenile pubic symphysiodesis (JPS) treatment in hip dysplasia-prone puppies with comparison to similar untreated control puppies.

Design: Controlled clinical case study.

Animals: Thirty-nine dysplastic puppies, of which six were part of the control group, with a positive Ortolani or hip distraction index (DI)≥0.

Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells.

The molecular mechanisms of Idiopathic Pulmonary Fibrosis (IPF) remain elusive. Transforming Growth Factor beta 1(TGF-beta1) is a key effector cytokine in the development of lung fibrosis. We used microarray and computational biology strategies to identify genes whose expression is significantly altered in alveolar epithelial cells (A549) in response to TGF-beta1, IL-4 and IL-13 and Epstein Barr virus.

Inclusion body myopathy associated with motor neuron syndrome: three case reports.

Background: Hereditary inclusion body myopathy (h-IBM) is an autosomal-recessive or autosomal-dominant hereditary disease characterized by peculiar findings in muscle biopsies which resemble those occurring in inclusion body myositis (IBM). The absence of an inflammatory infiltrate in myofibers in h-IBM is a relevant differential criterion between the two pathologies. Motor neuron diseases (MND) represent a group of disorders involving both upper and lower motor neurons, characterized by fasciculations, progressive muscle weakness, and muscle atrophy.

Use of portocaval venografts with ameroid constrictor placement and hepatic lobectomy for treatment of intralobular intrahepatic portocaval shunts in four dogs.

Liver lobectomy for complete attenuation of intrahepatic portosystemic shunts appears to be a safe and effective surgical treatment. When the intrahepatic shunt vessel can be definitively palpated within a liver lobe or its presence confirmed portographically, liver lobectomy represents a technically simple and effective method of complete shunt attenuation. To maintain portal pressure at an acceptable value after lobectomy, an extrahepatic portocaval shunt vessel can be created by use of an external jugular vein graft.

Cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs.

Objective: To evaluate efficacy and cost of using cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs.

Design: Clinical trial.

Animals: 12 dogs with perianal fistulas.

Juvenile pubic symphysiodesis in dysplastic puppies at 15 and 20 weeks of age.

Objective: To examine the effects of juvenile pubic symphysiodesis (JPS) on hip joint conformation, hip laxity, gait, and the development of degenerative joint disease (DJD) in dysplastic puppies operated at 15 and 20 weeks of age.

Study Design: Randomized controlled prospective study. ANIMALS-Eighteen female hound puppies with increased hip laxity.

Canine pubic symphysiodesis: investigation of electrocautery dose response by histologic examination and temperature measurement.

Objectives: To determine thermal necrosis zone and the maximal temperature achieved with various electrocautery doses applied to the pubic symphysis of immature dogs, and to establish the minimal electrocautery dose needed to affect thermal necrosis of the germinal chondrocytes of the immature canine pubis.

Study Design: A randomized, controlled, prospective study.

Animals: Twelve puppies, 15 to 17 weeks of age.

Effects of pubic symphysiodesis in dysplastic puppies.

Objective: To determine the long-term effects of juvenile pubic symphysiodesis (JPS) in dysplastic puppies.

Study Design: Prospective, randomized, clinical trial.

Animals: Seven dysplastic Chesapeake Bay retrievers and 2 beagle-crosses (BX1 and 2).

Mammary gland uptake of sodium Tc-pertechnetate in a cat with a drug-induced gynecomastia.

Sodium Tc-pertechnetate accumulated in the mammary glands of a male cat. It was determined that the uptake was attributable to gynecomastia induced by medroxyprogesterone acetate injections. Gynecomastia and pertechnetate uptake resolved following cessation of medroxyprogesterone acetate treatment.