Untargeted, High-Resolution Metabolomics in Pediatric Eosinophilic Esophagitis.

Background/objectives: Eosinophilic esophagitis (EoE) is an inflammatory disease of unclear etiology. The aim of this study was to use untargeted plasma metabolomics to identify metabolic pathway alterations associated with EoE to better understand the pathophysiology.

Methods: This prospective, case-control study included 72 children, aged 1-17 years, undergoing clinically indicated upper endoscopy (14 diagnosed with EoE and 58 controls).

Sex Differences in Blood Transcriptional Profiles and Clinical Phenotypes in Pediatric Patients with Eosinophilic Esophagitis.

Background: Eosinophilic esophagitis (EoE) is an increasingly recognized, chronic inflammatory disease. Recent reports suggest clinical differences between males and females.

Objective: To define the relevant molecular pathways that could be related to clinical phenotypes in children with EoE.

IgE antibodies and response to cow's milk elimination diet in pediatric eosinophilic esophagitis.

Milk is a common cause of eosinophilic esophagitis. Allergy testing does not predict response to dietary therapy. In this study, patients with low or undetectable IgE antibodies to milk achieved histologic remission with milk elimination.