Publications by authors named "Patrice Cunningham"
Cachexia, a complex wasting syndrome, significantly affects the quality of life and treatment options for cancer patients. Studies have reported a strong correlation between high platelet count and decreased survival in cachectic individuals. Therefore, this study aimed to investigate the immunopathogenesis of cancer cachexia using the Apc mouse model of spontaneous colorectal cancer.
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- Gastrointestinal pain and fatigue are key issues for patients with inflammatory bowel disease (IBD), with some experiencing abdominal pain even when their disease is inactive; Ojeok-san (OJS), a medicinal herb, shows potential in alleviating this pain but lacks research in IBD preclinical models.
- * The study aimed to evaluate the analgesic effects of OJS and its potential for addiction, while also examining tumor necrosis factor alpha (TNFα) from macrophages as a factor in IBD-related pain.
- * Results indicated that OJS effectively reduced pain responses in various IBD models without exhibiting rewarding properties or being influenced by TNFα levels from macrophages, suggesting its promise as a treatment for managing pain in IBD
A cachexia diagnosis is associated with a doubling in hospital stay and increased healthcare cost for cancer patients and most cachectic patients do not survive treatment. Unfortunately, complexity in treating cachexia is amplified by both the underlying malignancy and the anti-cancer therapy which can independently promote cachexia. Quercetin, an organic polyphenolic flavonoid, has demonstrated anti-inflammatory and antioxidant properties with promise in protecting against cancer and chemotherapy-induced dysfunction; however, whether quercetin is efficacious in maintaining muscle mass in tumor-bearing animals receiving chemotherapy has not been investigated.
View Article and Find Full Text PDFBackground: Quercetin is an organic flavonoid present in several fruits and vegetables. The anti-inflammatory, antiviral, antioxidant, cardio-protective, anti-carcinogenic and neuroprotective properties demonstrated by this dietary supplement endorses it as a possible treatment for inflammatory diseases and cancer. Unfortunately, conflicting research has cast uncertainties on the toxicity of quercetin.
View Article and Find Full Text PDFCancer patients can develop visceral, somatic, and neuropathic pain, largely due to the malignancy itself and its treatments. Often cancer patients and survivors turn to the use of complementary and alternative medicine (CAM) to alleviate pain and fatigue. Thus, it is necessary to investigate how CAM therapies work as novel analgesics to treat cancer pain.
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