Publications by authors named "Patrice Bourson"
Article Synopsis
- Analytical chemistry has become increasingly vital in archaeology, allowing researchers to analyze material remains with advanced instrumental techniques like Raman spectral imaging for better spatial and temporal data.
- Raman spectral imaging offers a non-invasive way to gather both spatial and spectral information about archaeological samples, but interpreting this data can be complex due to the intricate and often degraded nature of such artifacts.
- The study focuses on applying chemometric methods, particularly the MCR-ALS algorithm, to improve the extraction of meaningful spectral data from an archaeological mosaic fragment found in France, addressing challenges in accurately identifying minor chemical components amidst dominant signals.
Article Synopsis
- - Gelatin is a widely used biopolymer in medicine because it's safe and doesn't trigger inflammation, and it can form Ionogels with ionic liquids (ILs) as cosolvents for better drug delivery.
- - The study focuses on using a specific IL, 1-ethyl-3-methylpyridinium perfluorobutanesulfonate (FIL), with fish gelatin to enhance the solubility of drugs like Doxorubicin while maintaining the mechanical and nanostructural properties of the material.
- - Controlled release mechanisms of Doxorubicin and Mithramycin from different Ionogel formulations were compared to traditional gelatin hydrogels, highlighting the importance of structural design for
The incessant developments in the pharmaceutical and biomedical fields, particularly, customised solutions for specific diseases with targeted therapeutic treatments, require the design of multicomponent materials with multifunctional capabilities. Biodegradable polymers offer a variety of tailored physicochemical properties minimising health adverse side effects at a low price and weight, which are ideal to design matrices for hybrid materials. PLAs emerge as an ideal candidate to develop novel materials as are endowed withcombined ambivalent performance parameters.
View Article and Find Full Text PDFA series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles featuring different nanostructures were designed to generate multifunctional drug delivery systems with tailored release rates required for personalized treatment approaches. The global conception of the systems was considered from the desired customization of the drug release while featuring the viscoelastic properties needed for their ease of storage and posterior local administration as well as their biocompatibility and cell growth capability for the successful administration at the biomolecular level. The hydrogel matrix offers the support to develop a direct thermal method to convert the typical kinetic trapped nanostructures afforded by the formulation method whilst avoiding the detrimental nanoparticle agglomeration that diminishes their therapeutic effect.
View Article and Find Full Text PDFStereo-diblock copolymers of high molecular weight polylactide (PLA) were synthetized by the one pot-sequential addition method assisted by a heteroscorpionate catalyst without the need of a co-initiator. The alkyl zinc organometallic heteroscorpionate derivative (Zn(Et)(κ-bpzteH)] (bpzteH = 2,2-bis(3,5-dimethylpyrazol-1-yl)-1-para-tolylethoxide) proved to assist in the mechanism of reaction following a coordination-insertion process. Kinetic studies along with the linear correlation between monomer and number average molecular weight (M) conversion, and the narrow polydispersities supported the truly living polymerization character of the initiator, whereas matrix-assisted laser desorption/Ionization-time of flight (MALDI-TOF) studies showed a very low order of transesterification.
View Article and Find Full Text PDFArticle Synopsis
- The physical changes in polymers due to external factors are influenced by their molecular length and energy balance, necessitating advanced studies to understand these transformations.
- Researchers suggest using a multi-technique approach combining X-ray scattering, Raman spectroscopy, and Differential Scanning Calorimetry to study the structural changes in polymers at various scales.
- To maximize the analysis of data from these techniques, they recommend using multivariate analysis and data mining strategies, which were successfully applied in crystallization studies of a PVDF blend with a fluoroelastomer.
Article Synopsis
- Raman spectroscopy was employed to study how varying concentrations of urea in water affect the freezing point of the solution.
- The analysis focused on the phase transitions of urea aqueous solutions at low temperatures, specifically between -30 and 10 °C.
- This research allowed for the construction of an experimental phase diagram for the urea-water binary system.
Raman spectroscopy was used to study the NaCl aqueous solutions around the solid-liquid phase transition. Special attention was devoted to the modification induced by the salt on the OH stretching band of water. Investigations were carried out in the temperature range between -21 and 10 degrees C, for concentrations from 0 to 200 g/L.
View Article and Find Full Text PDFWe propose a new optical sensor to characterize the solid-liquid phase transition in salted solutions. The probe mainly consists of a Raman spectrometer that extracts the vibrational properties from the light scattered by the salty medium. The spectrum of the O-H stretching band was shown to be strongly affected by the introduction of NaCl and the temperature change as well.
View Article and Find Full Text PDF