Publications by authors named "Patima Sila"
Severe Malaria: Even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. Typical features at death are high parasite loads and obstructed micro- vasculature. Infected erythrocytes (IE) containing mature parasites bind to the host receptor heparan sulfate, which is also an important receptor for merozoite invasion.
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- Severe falciparum malaria causes red blood cells infected with the parasite to stick to blood vessel walls and other red cells, obstructing blood flow in critical organs.
- Heparin can help reverse this adhesion but has a risk of bleeding, while sevuparin aims to maintain the anti-adhesive benefits without significant anticoagulant effects.
- Research shows that sevuparin effectively disrupts rosette formation and inhibits the adherence of infected red blood cells to vascular cells, suggesting it could be a useful addition to standard malaria treatments.