Three-dimensional assessment of mandibular canal in different sagittal and growth patterns for safe placement of temporary skeletal anchorage devices: A prospective study.

Introduction: The primary objective of this study was to assess the 3-dimensional position of the mandibular canal (MC) in different craniofacial patterns to know about the safe placement of temporary skeletal anchorage devices using cone-beam computed tomography (CBCT). The secondary objectives were to assess sex differences and correlate the MC position with various factors.

Methods: This prospective, observational study was conducted on 90 patients, divided into 3 groups based on the sagittal pattern: skeletal Class I, Class II, and Class III.

Geographical Distribution, Host Range and Genetic Diversity of f. sp. Causing Wilt of Banana in India.

wilt of banana is a major production constraint in India, prompting banana growers to replace bananas with less remunerative crops. Effective disease management practices thus need to be developed and implemented to prevent further spread and damage caused by f. sp.

Dataset of leaves for quality assessment and machine learning applications.

is a significant medicinal herb extensively used in traditional oriental medicine and gaining global popularity. The primary constituents of leaves are triterpenoid saponins, which are predominantly believed to be responsible for its therapeutic properties. Ensuring the use of high-quality leaves in herbal medicine preparation is crucial across all medicinal practices.

How measurement noise limits the accuracy of brain-behaviour predictions.

Major efforts in human neuroimaging strive to understand individual differences and find biomarkers for clinical applications by predicting behavioural phenotypes from brain imaging data. To identify generalisable and replicable brain-behaviour prediction models, sufficient measurement reliability is essential. However, the selection of prediction targets is predominantly guided by scientific interest or data availability rather than psychometric considerations.

Multifaceted impact of HIV inhibitor dapivirine on triple negative breast cancer cells reveals potential entities as targets for novel therapy.

Breast cancer is the most common cancer in women worldwide. Many breast cancers originate from the cells lining the milk duct and some become invasive. Breast cancer lacking estrogen, progesterone receptors (ER-, PR-) and epidermal growth factor receptor 2 (HER2-) amplification, termed "Triple negative" (TNBC) is reported to frequently affect Black women and younger women.

Tuning fungal promoters for the expression of eukaryotic proteins.

Fungal systems, yeast as well as filamentous fungi, are effective platforms for producing recombinant eukaryotic proteins because of their efficient secretion, robust development features, and capacity for post-translational modification. However, to achieve optimum protein expression in fungal hosts, a precise regulation of gene expression levels is necessary. Promoters are critical cis-regulatory regions that drive gene expression.

Sleep Quality Improves Post Total Knee Arthroplasty: Addressing Early Disturbance and Risk Factors.

Objectives: Sleep is an important determinant of quality of life. Sleep disturbance is concomitant with end-stage knee osteoarthritis for which Total Knee Arthroplasty (TKA) is the most commonly done procedure. However, literature on this topic is lacking in terms of the impact of sleep quality on patient satisfaction after arthroplasty, especially the adverse associations of surgery on sleep quality.

Large language models surpass human experts in predicting neuroscience results.

Scientific discoveries often hinge on synthesizing decades of research, a task that potentially outstrips human information processing capacities. Large language models (LLMs) offer a solution. LLMs trained on the vast scientific literature could potentially integrate noisy yet interrelated findings to forecast novel results better than human experts.

Characterising Sinonasal Pneumatization in Patients with Nasal Septal Deviation: A CBCT-Based Study.

Aim: This study aimed to investigate the presence and correlation of paranasal sinus pneumatization among patients with and without nasal septal deviations (NSD), to enhance clinical understanding of sinonasal anatomical variations.

Materials And Methods: It is descriptive, retrospective study under a monocentric, utilizing institutional archives. 30 subjects with NSD and 30 without NSD were selected.

A novel SERPINC1 c.119G>A (p.Cys40Tyr) mutation with variable clinical expression in an Indian family.

Hereditary antithrombin (AT) deficiency due to mutations in SERPINC1 is known to be the most severe form of thrombophilia. We report three members in a family with hereditary AT deficiency with a novel mutation in exon 2 of SERPINC1, that is c.119 G>A (p.

Cephalometric landmark annotation using transfer learning: Detectron2 and YOLOv8 baselines on a diverse cephalometric image dataset.

Background: Cephalometric landmark annotation is a key challenge in radiographic analysis, requiring automation due to its time-consuming process and inherent subjectivity. This study investigates the application of advanced transfer learning techniques to enhance the accuracy of anatomical landmarks in cephalometric images, which is a vital aspect of orthodontic diagnosis and treatment planning.

Methods: We assess the suitability of transfer learning methods by employing state-of-the-art pose estimation models.

Effect of Rice Residue Biochar on Lead Remediation, Growth, and Micronutrient Uptake in Indian Mustard (Brassica juncea (L.) Czern.) Cultivated in Contaminated Soil.

A pot experiment at Punjab Agricultural University, Ludhiana, India, assessed rice residue biochar's effect on remediating lead and cadmium in soil and on Indian mustard growth. Soil spiked with Cd (0, 10, 25 mg kg⁻¹) and Pb (0, 25, 50 mg kg⁻¹) was amended with biochar (0, 0.5, 1, 2% w/w) in a completely randomized design with three replications.

Evaluation of Anxiolytic Activity of Angiotensin Receptor Blockers Using Actophotometer Test in Wistar Rats.

Introduction Anxiety disorders are common mental illnesses impacting quality of life, with current treatments like benzodiazepines and selective serotonin reuptake inhibitors (SSRIs) facing limitations due to side effects. Angiotensin receptor blockers (ARBs), used primarily for hypertension, have shown potential neuropsychiatric benefits, including anxiolytic effects. This study explores the anxiolytic effects of two ARBs, telmisartan and losartan, by evaluating locomotor activity in Wistar rats, aiming to identify new treatment options for anxiety through modulation of the renin-angiotensin system.

Postoperative Tongue Exercises for Ankyloglossia Following Lingual Frenectomy: A Case Report.

Ankyloglossia, also named tongue-tie, is an innate developmental anomaly where the lingual frenum appears anchored to the sublingual space. Even though it is not considered a major congenital condition, it can create a variety of problems, such as difficulty in feeding newborns, difficulty in mastication, speech problems, poor oral hygiene, malocclusion, and hindrance in social interaction because of restricted tongue movements. Lingual frenectomy is the treatment of choice.

Quantification of Salivary Chromogranin A Levels during Routine Dental Procedures in Children: An Study.

Background: Routine dental procedures frequently involve invasive treatment, multiple injections, and the use of sharp, high-speed cutting instruments, and treatment is often extended over several visits, which are said to be stress-provoking events. Salivary chromogranin A (CgA) is a biomarker that can help clinicians evaluate and quantify the stress experienced by a child during these procedures.

Aim: To quantify the changes in salivary CgA levels in children before, during, and after routine dental procedures for multiple appointments.

Development of a Artificial Intelligence Dental Anxiety Scale (AI -CDAS) For Children: Validation And Reliability.

Assessing children's pain using patient-based pain scales can be challenging. Hence, there is a need of new version Artificial Intelligence Child Dental Anxiety Scale (AI-CDAS) to scale and test its psychometric properties (validity and reliability). This study was conducted to evaluate the validity and reliability of Artificial Intelligence version of the Child Dental Anxiety Scale (AI-CDAS) for anxiety detection scale in children using face as a response set from October 2022 to December 2023.

CONFORMATIONAL FLEXIBILITY IS A CRITICAL FACTOR IN DESIGNING BROAD-SPECTRUM HUMAN NOROVIRUS PROTEASE INHIBITORS.

Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available. The protease encoded by the HuNoV genome plays a critical role in virus replication by cleaving the polyprotein and is, therefore, an excellent target for developing small molecule inhibitors.

Patient Profile-Based Management with Nintedanib in Patients with Idiopathic Pulmonary Fibrosis.

A severe and progressive interstitial lung disease (ILD) known as idiopathic pulmonary fibrosis (IPF) has an unknown etiology with poorly defined mechanisms of development. Among the currently prescribed pharmacological interventions for IPF, nintedanib demonstrates the ability to decelerate the deterioration of lung function and yield positive clinical outcomes. Multiple randomized placebo-controlled trials have confirmed the efficacy and acceptable safety profile of nintedanib.

Author Correction: Predictive evolution of metabolic phenotypes using model-designed environments.

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